Kidney Cancer and Potential Use of Urinary Extracellular Vesicles

被引：1
作者：
Le, Linh Nguy-Hoang [1 ,2 ]
Munir, Javaria [3 ]
Kim, Eun-Bit [2 ]
Ryu, Seongho [1 ,2 ]
机构：
[1] Soonchunhyang Univ, Dept Integrated Biomed Sci, Cheonan, South Korea
[2] Soonchunhyang Univ, Soonchunhyang Inst Medbio Sci SIMS, Cheonan, South Korea
[3] Univ Nebraska Lincoln, Dept Nutr & Hlth Sci, Lincoln, NE USA
来源：
ONCOLOGY REVIEWS | 2024年 / 18卷
基金：
新加坡国家研究基金会;
关键词：
urine; extracellular vesicle; exosome; kidney cancer; renal cell carcinoma; biomarker; LIQUID BIOPSY; BIOMARKERS; PROTEIN; RESISTANCE; MICRORNAS; EXOSOMES; SERUM;
D O I：
10.3389/or.2024.1410450
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Kidney cancer is the 14th most common cancer globally. The 5-year relative survival rate of kidney cancer at a localized stage is 92.9% and it declines to 17.4% in metastatic stage. Currently, the most accurate method of its diagnosis is tissue biopsy. However, the invasive and costly nature of biopsies makes it undesirable in many patients. Therefore, novel biomarkers for diagnosis and prognosis should be explored. Urinary extracellular vesicles (uEVs) are small vesicles (50-200 nm) in urine carrying nucleic acids, proteins and lipids as their cargos. These uEVs' cargos can provide non-invasive alternative to monitor kidney health. In this review, we have summarized recent studies investigating potential use of uEVs' cargos as biomarkers in kidney cancer for diagnosis, prognosis and therapeutic intervention.
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页数：7
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