Escalating caffeine dose-dependently increases alcohol consumption in adult male, but not female, C57BL/6J mice

被引:3
作者
Swanson, Bradyn N. [1 ]
Lewis, Sydney A. [1 ]
Kaur, Amarpreet [1 ]
Berry, Jennifer N. [1 ]
机构
[1] Butler Univ, Dept Psychol, 4600 Sunset Ave, Indianapolis, IN 46208 USA
关键词
Ethanol; Caffeine; Mice; Adult; Consumption; ENERGY DRINK CONSUMPTION; HIGH-RISK DRINKING; INTERMITTENT ACCESS; ETHANOL DRINKING; ADOLESCENT; ASSOCIATIONS; BEHAVIORS; COCKTAILS; PATTERNS; EXPOSURE;
D O I
10.1016/j.pbb.2024.173806
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Although previous research has illustrated the effects of the consumption of alcohol and caffeine individually, less research has focused on the popular combination of the two drugs. The increase in alcohol consumption when combined with caffeine has led to the idea that the stimulant effects of caffeine may mask the depressant effects of alcohol, and this may contribute to increased binge drinking as the individual feels more awake and stimulated. Preclinical research has shown various effects of combined alcohol and caffeine where several studies show decreased alcohol consumption and others show increased alcohol consumption and even binge -like drinking. Results from a previous study in our lab indicate that intermittent access (IA) to steady levels of low (0.015 %) but not moderate (0.03 %) caffeine increased alcohol consumption in male C57BL/6J mice. The current studies further investigated the sex and dose differences in adult mice receiving varying concentrations of caffeine on combined alcohol intake. In Experiment 1, adult mice ( n = 50, 25 males and 25 females) had IA to one of the following experimental bottles throughout the 4 week period: water, alcohol (10 % v /v), caffeine (0.015 % w / v ), or 10 % alcohol +0.015 % caffeine. In Experiment 2, adult mice ( n = 70, 35 males and 35 females) were given IA to one of the following experimental bottles: water, alcohol (10 % v /v; steady, maintained throughout the 4 weeks), caffeine (increasing 0.01 % to 0.015 % to 0.02 % to 0.03 % weekly), or 10 % alcohol +increasing caffeine (at the previously mentioned concentrations). When both caffeine and alcohol concentrations remained steady throughout the 4 weeks, there was no change in alcohol consumption. Chronic exposure to IA caffeine led to increased locomotor activity and decreased freezing episodes when tested in the open field test approximately 6 h after removal of the bottles. In Experiment 2, caffeine dose -dependently increased alcohol co -consumption in male mice whereas female mice consumed less alcohol when it was presented in conjunction with caffeine. The results in males are in line with clinical literature suggesting that the combination of alcohol and caffeine may lead to increased stimulation and alcohol drinking. Additionally, these studies provide evidence that the escalation of caffeine is crucial when investigating alcohol and caffeine coconsumption using the IA paradigm.
引用
收藏
页数:13
相关论文
共 44 条
[1]   Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats [J].
Amodeo, Leslie R. ;
Wills, Derek N. ;
Sanchez-Alavez, Manuel ;
Nguyen, William ;
Conti, Bruno ;
Ehlers, Cindy L. .
ALCOHOL, 2018, 73 :57-66
[2]   Effects of caffeine on alcohol-related changes in behavioural control and perceived intoxication in light caffeine consumers [J].
Attwood, Angela S. ;
Rogers, Peter J. ;
Ataya, Alia F. ;
Adams, Sally ;
Munafo, Marcus R. .
PSYCHOPHARMACOLOGY, 2012, 221 (04) :551-560
[3]   EVALUATION OF THE CENTRAL EFFECTS OF ALCOHOL AND CAFFEINE INTERACTION [J].
AZCONA, O ;
BARBANOJ, MJ ;
TORRENT, J ;
JANE, F .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 40 (04) :393-400
[4]   Alcohol and energy drink use among adolescents seeking emergency department care [J].
Bonar, Erin E. ;
Cunningham, Rebecca M. ;
Polshkova, Svitlana ;
Chermack, Stephen T. ;
Blow, Frederic C. ;
Walton, Maureen A. .
ADDICTIVE BEHAVIORS, 2015, 43 :11-17
[5]   Drinking patterns and risk behaviors associated with combined alcohol and energy drink consumption in college drinkers [J].
Brache, Kristina ;
Stockwell, Timothy .
ADDICTIVE BEHAVIORS, 2011, 36 (12) :1133-1140
[6]   Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse [J].
Carnicella, Sebastien ;
Ron, Dorit ;
Barak, Segev .
ALCOHOL, 2014, 48 (03) :243-252
[7]   The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood [J].
Diaz-Granados, Jaime L. ;
Graham, Danielle L. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2007, 31 (12) :2020-2027
[8]   Caffeine reversal of ethanol effects on the multiple sleep latency test, memory, and psychomotor performance [J].
Drake, CL ;
Roehrs, T ;
Turner, L ;
Scofield, HM ;
Roth, T .
NEUROPSYCHOPHARMACOLOGY, 2003, 28 (02) :371-378
[9]   Low but not moderate amounts of caffeine increase co-consumption of ethanol in C57BL/6J mice [J].
Evans, Melissa J. ;
Jenkins, Montana D. ;
Berry, Jennifer N. .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2021, 208
[10]  
Ferreira SE, 2004, PHYSIOL BEHAV, V82, P841, DOI [10.1016/S0031-9384(04)00284-7, 10.1016/j.physbeh.2004.06.017]