The Role of Collagens in Atopic Dermatitis

被引：1

作者：

Szalus, Krzysztof ^{[1
]}

Trzeciak, Magdalena ^{[1
]}

机构：

[1] Med Univ Gdansk, Fac Med, Dept Dermatol Venereol & Allergol, PL-80214 Gdansk, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 14期

关键词：

atopic dermatitis; collagens; extracellular matrix; pathogenesis; FILAGGRIN GENE; SKIN; EXPRESSION; DEFICIENCY; IL-19; CELLS;

D O I：

10.3390/ijms25147647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting both children and adults. The clinical picture of AD manifests in typical skin lesions, such as localized eczema and dry skin, with dominant, persistent itching that leads to sleep disturbances. The pathophysiology of AD has been extensively investigated with respect to epigenetic and genetic factors, skin barrier defects, as well as immunological and microbial disorders. However, to date, the involvement of extracellular matrix (ECM) elements has received limited attention. Collagen, a major component of the ECM, may serve as a therapeutic target for the future treatment of AD. This paper summarizes the role of collagens, which are the most abundant components of the extracellular matrix in AD.

引用

页数：10

共 48 条

[1] Skin Barrier Defects in Atopic Dermatitis [J].

Agrawal, Rachana ;

Woodfolk, Judith A. .

CURRENT ALLERGY AND ASTHMA REPORTS, 2014, 14 (05)

[2] The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group [J].

Alexander, H. ;

Paller, A. S. ;

Traidl-Hoffmann, C. ;

Beck, L. A. ;

De Benedetto, A. ;

Dhar, S. ;

Girolomoni, G. ;

Irvine, A. D. ;

Spuls, P. ;

Su, J. ;

Thyssen, J. P. ;

Vestergaard, C. ;

Werfel, T. ;

Wollenberg, A. ;

Deleuran, M. ;

Flohr, C. .

BRITISH JOURNAL OF DERMATOLOGY, 2020, 182 (06) :1331-1342

[3] From Structure to Phenotype: Impact of Collagen Alterations on Human Health [J].

Arseni, Lavinia ;

Lombardi, Anita ;

Orioli, Donata .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (05)

[4] Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases [J].

Bhattacharjee, Oindrila ;

Ayyangar, Uttkarsh ;

Kurbet, Ambika S. ;

Ashok, Driti ;

Raghavan, Srikala .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7

[5] Atopic dermatitis: a disease of altered skin barrier and immune dysregulation [J].

Boguniewicz, Mark ;

Leung, Donald Y. M. .

IMMUNOLOGICAL REVIEWS, 2011, 242 :233-246

[6] The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies [J].

Brunner, Patrick M. ;

Guttman-Yassky, Emma ;

Leung, Donald Y. M. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (04) :S65-S76

[7] Variable TH2/TH17-skewing places Chinese atopic dermatitis and psoriasis on an inflammatory spectrum [J].

Chan, T. C. ;

Sanyal, R. D. ;

Pavel, A. B. ;

Glickman, J. ;

Zheng, X. ;

Cho, Y. ;

Tsai, T. ;

Peng, X. ;

Krueger, J. G. ;

Guttman-Yassky, E. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (05) :S10-S10

[8]

Chopra S., 2023, Acta Derm. Venereol, V103

[9] Atopic dermatitis endotypes and implications for targeted therapeutics [J].

Czarnowicki, Tali ;

He, Helen ;

Krueger, James G. ;

Guttman-Yassky, Emma .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (01) :1-11

[10] Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population [J].

Czarnowicki, Tali ;

Gonzalez, Juana ;

Shemer, Avner ;

Malajian, Dana ;

Xu, Hui ;

Zheng, Xiuzhong ;

Khattri, Saakshi ;

Gilleaudeau, Patricia ;

Sullivan-Whalen, Mary ;

Suarez-Farinas, Mayte ;

Krueger, James G. ;

Guttman-Yassky, Emma .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 136 (01) :104-U215

← 1 2 3 4 5 →