Focal Crescentic Glomerulonephritis Superimposed on Myeloproliferative Disease-Related Glomerulopathy in a Case of Myelofibrosis

被引：0

作者：

Kunpara, Janmejay Ashvinkumar ^{[1
,3
]}

Darji, Bhavya Prakash ^{[2
]}

Patel, Himanshu Arvindbhai ^{[1
]}

Patwari, Devang ^{[1
]}

Patel, Sujit Shaileshbhai ^{[1
]}

Darji, Prakash Ishwarlal ^{[1
]}

机构：

[1] Zydus Hosp, Dept Nephrol, Ahmadabad, India

[2] GCS Med Coll, Ahmadabad, Gujarat, India

[3] Shakti Plot 8 Corner, Morbi 363641, Gujarat, India

来源：

INDIAN JOURNAL OF NEPHROLOGY | 2024年 / 34卷 / 01期

关键词：

Glomerulonephritis; myelofibrosis; pauci-immune; proliferative; POLYCYTHEMIA-VERA; GROWTH-FACTOR; THROMBOSIS; NEOPLASMS; BETA;

D O I：

10.4103/ijn.ijn_218_22

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Proliferative glomerulonephritis in myelofibrosis is a very rare. Mesangial proliferation and sclerosis with changes of chronic thrombotic microangiopathy have been reported, but pauci-immune focal crescentic glomerulonephritis has not been described so far. Herein, we present a 68-year-old male who was a known case of myelofibrosis and presented with rapidly progressive glomerulonephritis and nephrotic range proteinuria. He was diagnosed as anti-neutrophil cytoplasmic antibody (ANCA)-negative focal crescentic glomerulonephritis, and he responded well to a course of intravenous methylprednisolone and cyclophosphamide. Pauci-immune focal crescentic glomerulonephritis may occur in myelofibrosis without ANCA and may be related to unknown pathogenetic mechanisms in myeloproliferative disorders or suggest any superimposed pathology that might respond well to immunosuppressants.

引用

页码：64 / 66

页数：3

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