The role of reactive oxygen species in gastric cancer

被引：1

作者：

Wang, Yuqi ^{[1
,2
,3
,4
]}

Xu, Jingli ^{[2
,3
,4
]}

Fu, Zhenjie ^{[2
,3
,4
]}

Zhang, Ruolan ^{[2
,3
,4
]}

Zhu, Weiwei ^{[2
,3
,4
]}

Zhao, Qianyu ^{[2
,3
,4
]}

Wang, Ping ^{[1
]}

Hu, Can ^{[2
,3
,4
]}

Cheng, Xiangdong ^{[2
,3
,4
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

[2] Zhejiang Canc Hosp, Dept Gastr Surg, Hangzhou 310022, Peoples R China

[3] Key Lab Prevent Diag & Therapy Upper Gastrointesti, Hangzhou 310022, Peoples R China

[4] Zhejiang Canc Hosp, Zhejiang Prov Res Ctr Upper Gastrointestinal Tract, Hangzhou 310022, Peoples R China

来源：

CANCER BIOLOGY & MEDICINE | 2024年 / 21卷 / 09期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Gastric cancer; reactive oxygen species; ROS; antitumor therapy; natural products; pharmacology; ROS GENERATION; APOPTOSIS; MITOCHONDRIA; CELLS; METABOLISM; INDUCTION; EXTRACT; PATHWAY; STRESS; CYCLE;

D O I：

10.20892/j.issn.2095-3941.2024.0182

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.

引用

页码：740 / 753

页数：14

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