Liquid-liquid phase separation in innate immunity

被引：7

作者：

Liu, Dawei ^{[1
]}

Yang, Jinhang ^{[1
]}

Cristea, Ileana M. ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

TRENDS IN IMMUNOLOGY | 2024年 / 45卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PML NUCLEAR-BODIES; AICARDI-GOUTIERES-SYNDROME; CYCLIC GMP-AMP; RIG-I; ENDOPLASMIC-RETICULUM; DISORDERED PROTEINS; AUTOIMMUNE-DISEASE; RNA HELICASE; DNA; IFI16;

D O I：

10.1016/j.it.2024.04.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intrinsic and innate immune responses are essential lines of defense in the body's constant surveillance of pathogens. The discovery of liquid-liquid phase separation (LLPS) as a key regulator of this primal response to infection brings an updated perspective to our understanding of cellular defense mechanisms. Here, we review the emerging multifaceted role of LLPS in diverse aspects of mammalian innate immunity, including DNA and RNA sensing and inflammasome activity. We discuss the intricate regulation of LLPS by posttranslational modifications (PTMs), and the subversive tactics used by viruses to antagonize LLPS. This Review, therefore, underscores the significance of LLPS as a regulatory node that offers rapid and plastic control over host immune signaling, representing a promising target for future therapeutic strategies.

引用

页码：454 / 469

页数：16

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