Unveiling Biosensing Innovations: Laser Scattering Sensor and Gold Nanoparticles-Decorated Ti3C2 MXene Composite for Enhanced Biosensing Applications

Nanomaterials have revolutionized the field of biosensors, offering unprecedented opportunities for enhanced sensitivity, selectivity, and miniaturization. Various nanomaterials, including metallic nanoparticles, carbon-based nanomaterials, and nanocomposites, have been extensively explored for biosensing applications. Among these, MXene stands out as a particularly interesting 2D nanomaterial, with numerous applications because of its exceptional properties. The main objective of this letter was to develop a novel laser scattering biosensor capable of detecting analytes through the aggregation of functionalized gold nanoparticle-decorated (Ti3C2)T-x MXene composites, leveraging the unique characteristics of both materials. Here, we integrated these biosensors with a fluidic system, achieving a rapid, sensitive, and cost-effective detection of various analytes, thereby facilitating high-throughput analysis, miniaturization, and automation.