Differential Antibacterial Effects of Chiral Co3O4

被引：0
|
作者：
Sun, Jia [1 ,2 ]
Song, Shanshan [1 ,2 ]
Guo, Caoyu [1 ,2 ]
Liu, Liqiang [1 ,2 ]
Sun, Maozhong [1 ,2 ]
Kuang, Hua [1 ,2 ]
Xu, Chuanlai [1 ,2 ]
Guo, Lingling [1 ,2 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Resources, Wuxi 214122, Peoples R China
[2] Jiangnan Univ, Sch Food Sci & Technol, Int Joint Res Lab Biointerface & Biodetect, Wuxi 214122, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2024年 / 40卷 / 06期
基金：
国家重点研发计划;
关键词：
Chiral material; Antibacterial property; Co3O4; Antimicrobial resistance; NANOPARTICLES;
D O I：
10.1007/s40242-024-4036-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
With the global spread of antimicrobial resistance, it is imperative to satisfy the need to develop novel antibacterial agents. Here, we synthesized chiral Co3O4 nanoparticles (NPs) with obvious bactericidal effects. It was found that the circular dichroism (CD) spectra of L-Co3O4 NPs and D-Co3O4 NPs exhibited perfect mirror image inversion. Specifically, the survival rate of primary uterine fibroblast (PCS)cells reached above 90% by co-culturing with chiral Co3O4 NPs. Besides, the chiral Co3O4 NPs showed obvious killing ability on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli O157:H7) bacteria both in vitro and in vivo. Particularly, D-Co3O4 NPs showed better antibacterial activity. Mechanistic studies confirmed that the level of reactive oxygen species level generated by D-Co3O4 NPs was higher than that of L-Co3O4 NPs. Overall, the synthesized D-Co3O4 NPs have the potential to become a kind of novel antibacterial nanomaterials. [GRAPHICS] .
引用
收藏
页码：1134 / 1140
页数：7
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