Antibiotic resistance: A key microbial survival mechanism that threatens public health

被引：21

作者：

Abbas, Amna ^{[1
]}

Barkhouse, Alexandra ^{[1
]}

Hackenberger, Dirk ^{[1
]}

Wright, Gerard D. ^{[1
]}

机构：

[1] McMaster Univ, Michael G DeGroote Inst Infect Dis Res, David Braley Ctr Antibiot Discovery, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

来源：

CELL HOST & MICROBE | 2024年 / 32卷 / 06期

基金：

加拿大健康研究院;

关键词：

BACTERIAL-RESISTANCE; GENES; RESISTOME; DRUGS;

D O I：

10.1016/j.chom.2024.05.015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibiotic resistance (AMR) is a global public health threat, challenging the effectiveness of antibiotics in combating bacterial infections. AMR also represents one of the most crucial survival traits evolved by bacteria. Antibiotics emerged hundreds of millions of years ago as advantageous secondary metabolites produced by microbes. Consequently, AMR is equally ancient and hardwired into the genetic fabric of bacteria. Human use of antibiotics for disease treatment has created selection pressure that spurs the evolution of new resistance mechanisms and the mobilization of existing ones through bacterial populations in the environment, animals, and humans. This integrated web of resistance elements is genetically complex and mechanistically diverse. Addressing this mode of bacterial survival requires innovation and investment to ensure continued use of antibiotics in the future. Strategies ranging from developing new therapies to applying artificial intelligence in monitoring AMR and discovering new drugs are being applied to manage the growing AMR crisis.

引用

页码：837 / 851

页数：15

共 124 条

[1] An enzyme from bacteria able to destroy penicillin [J].

Abraham, EP ;

Chain, E .

NATURE, 1940, 146 :837-837

[2] CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database [J].

Alcock, Brian P. ;

Huynh, William ;

Chalil, Romeo ;

Smith, Keaton W. ;

Raphenya, Amogelang R. ;

Wlodarski, Mateusz A. ;

Edalatmand, Arman ;

Petkau, Aaron ;

Syed, Sohaib A. ;

Tsang, Kara K. ;

Baker, Sheridan J. C. ;

Dave, Mugdha ;

McCarthy, Madeline C. ;

Mukiri, Karyn M. ;

Nasir, Jalees A. ;

Golbon, Bahar ;

Imtiaz, Hamna ;

Jiang, Xingjian ;

Kaur, Komal ;

Kwong, Megan ;

Liang, Zi Cheng ;

Niu, Keyu C. ;

Shan, Prabakar ;

Yang, Jasmine Y. J. ;

Gray, Kristen L. ;

Hoad, Gemma R. ;

Jia, Baofeng ;

Bhando, Timsy ;

Carfrae, Lindsey A. ;

Farha, Maya A. ;

French, Shawn ;

Gordzevich, Rodion ;

Rachwalski, Kenneth ;

Tu, Megan M. ;

Bordeleau, Emily ;

Dooley, Damion ;

Griffiths, Emma ;

Zubyk, Haley L. ;

Brown, Eric D. ;

Maguire, Finlay ;

Beiko, Robert G. ;

Hsiao, William W. L. ;

Brinkman, Fiona S. L. ;

Van Domselaar, Gary ;

McArthur, Andrew G. .

NUCLEIC ACIDS RESEARCH, 2023, 51 (D1) :D690-D699

[3]

[Anonymous], 2022, COVID-19: U.S. Impact on Antimicrobial Resistance, DOI DOI 10.15620/CDC:117915

[4]

[Anonymous], 2024, DOLLAR GENERAL

[5] PATRIC as a unique resource for studying antimicrobial resistance [J].

Antonopoulos, Dionysios A. ;

Assaf, Rida ;

Aziz, Ramy Karam ;

Brettin, Thomas ;

Bun, Christopher ;

Conrad, Neal ;

Davis, James J. ;

Dietrich, Emily M. ;

Disz, Terry ;

Gerdes, Svetlana ;

Kenyon, Ronald W. ;

Machi, Dustin ;

Mao, Chunhong ;

Murphy-Olson, Daniel E. ;

Nordberg, Eric K. ;

Olsen, Gary J. ;

Olson, Robert ;

Overbeek, Ross ;

Parrello, Bruce ;

Pusch, Gordon D. ;

Santerre, John ;

Shukla, Maulik ;

Stevens, Rick L. ;

VanOeffelen, Margo ;

Vonstein, Veronika ;

Warren, Andrew S. ;

Wattam, Alice R. ;

Xia, Fangfang ;

Yoo, Hyunseung .

BRIEFINGS IN BIOINFORMATICS, 2019, 20 (04) :1094-1102

[6] Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia [J].

Aranzana-Climent, Vincent ;

Hughes, Diarmaid ;

Cao, Sha ;

Tomczak, Magdalena ;

Urbas, Malgorzata ;

Zabicka, Dorota ;

Lundberg, Carina Vingsbo ;

Hansen, Jon ;

Lindberg, Johan ;

Hobbie, Sven N. ;

Friberg, Lena E. .

CLINICAL MICROBIOLOGY AND INFECTION, 2022, 28 (10) :1367-1374

[7] Horizontal gene transfer and adaptive evolution in bacteria [J].

Arnold, Brian J. ;

Huang, I-Ting ;

Hanage, William P. .

NATURE REVIEWS MICROBIOLOGY, 2022, 20 (04) :206-218

[8] The need for One Health systems-thinking approaches to understand multiscale dissemination of antimicrobial resistance [J].

Arnold, Kathryn E. ;

Laing, Gabrielle ;

McMahon, Barry J. ;

Fanning, Seamus ;

Stekel, Dov J. ;

Pahl, Ole ;

Coyne, Lucy ;

Latham, Sophia M. ;

McIntyre, K. Marie .

LANCET PLANETARY HEALTH, 2024, 8 (02) :e124-e133

[9] Impact of Pneumococcal Conjugate Vaccines on Antibiotic-Nonsusceptible Invasive Pneumococcal Disease in the United States [J].

Bajema, Kristina L. ;

Gierke, Ryan ;

Farley, Monica M. ;

Schaffner, William ;

Thomas, Ann ;

Reingold, Arthur L. ;

Harrison, Lee H. ;

Lynfield, Ruth ;

Burzlaff, Kari E. ;

Petit, Susan ;

Barnes, Meghan ;

Torres, Salina ;

Snippes Vagnone, Paula M. ;

Beall, Bernard ;

Pilishvili, Tamara .

JOURNAL OF INFECTIOUS DISEASES, 2022, 226 (02) :342-351

[10] Evolutionary Pathways and Trajectories in Antibiotic Resistance [J].

Baquero, F. ;

Martinez, J. L. ;

Lanza, V. F. ;

Rodriguez-Beltran, J. ;

Galan, J. C. ;

San Millan, A. ;

Canton, R. ;

Coque, T. M. .

CLINICAL MICROBIOLOGY REVIEWS, 2021, 34 (04)

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