Management of liver and gastrointestinal toxicity induced by immune checkpoint inhibitors: Position statement of the AEEH-AEG-SEPD-SEOM-GETECCU

被引：0

作者：

Riveiro-Barciela, Mar ^{[1
,2
,3
]}

Carballal, Sabela ^{[2
,4
,5
]}

Diaz-Gonzalez, Alvaro ^{[6
]}

Manosa, Miriam ^{[2
,7
]}

Gallego-Plazas, Javier ^{[8
]}

Cubiella, Joaquin ^{[2
,9
]}

Jimenez-Fonseca, Paula ^{[10
]}

Varela, Maria ^{[11
]}

Menchen, Luis

Sangro, Bruno

Fernandez-Montes, Ana

Mesonero, Francisco

Rodriguez-Gandia, Miguel angel

Rivera, Fernando

Londono, Maria-Carlota ^{[2
,5
]}

机构：

[1] Hosp Univ Vall dHebron, Vall Hebron Barcelona Hosp Campus, Internal Med Dept, Liver Unit, Barcelona, Spain

[2] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain

[3] Univ Autonoma Barcelona UAB, Dept Enfermeria, Bellaterra, Spain

[4] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS i, Gastroenterol Dept, Barcelona, Spain

[5] Univ Barcelona, Barcelona, Spain

[6] Hosp Univ Marques Valdecilla, Gastroenterol Dept, Grp Invest Clin & Traslac Enfermedades Digest, Inst Investigac Valdecilla IDIVAL, Santander, Spain

[7] Hosp Universitari Germans Trias i Pujol, Gastroenterol Dept, Badalona, Spain

[8] Hosp Gen Univ Elche, Med Oncol Dept, Elche, Spain

[9] Hosp Univ Ourense, Gastroenterol Dept, Orense, Spain

[10] Hosp Univ Cent Asturias, Med Oncol Dept, ISPA, Oviedo, Spain

[11] Univ Oviedo, Hosp Univ Cent Asturias, Gastroenterol Dept, IUOPA,ISPA,FINBA, Oviedo, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2024年 / 47卷 / 04期

关键词：

Immunotherapy; Immune checkpoint inhibitors; Toxicity; Hepatitis; Colitis; Drug-induced liver injury; Immune-related adverse events; Diarrhea; CELL LUNG-CANCER; NIVOLUMAB-RELATED CHOLANGITIS; ADVERSE EVENTS; METASTATIC MELANOMA; PD-1/PD-L1; INHIBITORS; CLINICAL-TRIALS; INDUCED COLITIS; DOUBLE-BLIND; HEPATOCELLULAR-CARCINOMA; SCLEROSING CHOLANGITIS;

D O I：

10.1016/j.gastrohep.2023.10.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The development of the immune checkpoint inhibitors (ICI) is one of the most remarkable achievements in cancer therapy in recent years. However, their exponential use has led to an increase in immune -related adverse events (irAEs). Gastrointestinal and liver events encompass hepatitis, colitis and upper digestive tract symptoms accounting for the most common irAEs, with incidence rates varying from 2% to 40%, the latter in patients undergoing combined ICIs therapy. Based on the current scientific evidence derived from both randomized clinical trials and real -world studies, this statement document provides recommendations on the diagnosis, treatment and prognosis of the gastrointestinal and hepatic ICI -induced adverse events.

引用

页码：401 / 432

页数：32

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