M1/M2 macrophage-targeted nanotechnology and PROTAC for the treatment of atherosclerosis

被引：4
作者：
Ma, Yupeng [1 ,2 ]
Yang, Xiaofan [1 ,2 ]
Ning, Ke [1 ,2 ]
Guo, Haidong [1 ,2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Sch Integrat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Sch Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
来源：
LIFE SCIENCES | 2024年 / 352卷
基金：
中国国家自然科学基金;
关键词：
Atherosclerosis; Macrophage; Nanotechnology; PROTAC; CERIUM OXIDE NANOPARTICLES; ENDOPLASMIC-RETICULUM STRESS; TIO2; NANOPARTICLES; IN-VIVO; ANTIINFLAMMATORY PROPERTIES; INTRAPLAQUE HEMORRHAGE; M2; MACROPHAGES; POLARIZATION; INFLAMMATION; APOPTOSIS;
D O I：
10.1016/j.lfs.2024.122811
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Macrophages play key roles in atherosclerosis progression, and an imbalance in M1/M2 macrophages leads to unstable plaques; therefore, M1/M2 macrophage polarization-targeted treatments may serve as a new approach in the treatment of atherosclerosis. At present, there is little research on M1/M2 macrophage polarizationtargeted nanotechnology. Proteolysis-targeting chimera (PROTAC) technology, a targeted protein degradation technology, mediates the degradation of target proteins and has been widely promoted in preclinical and clinical applications as a novel therapeutic modality. This review summarizes the recent studies on M1/M2 macrophage polarization-targeted nanotechnology, focusing on the mechanism and advantages of PROTACs in M1/M2 macrophage polarization as a new approach for the treatment of atherosclerosis.
引用
收藏
页数：11
相关论文
共 50 条
[41]   Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization [J].
Xie, J. W. ;
Wang, Y. ;
Xiao, K. ;
Xu, H. ;
Luo, Z. Y. ;
Li, L. ;
Pei, F. X. ;
Kraus, V. B. ;
Huang, Z. Y. .
OSTEOARTHRITIS AND CARTILAGE, 2021, 29 (07) :1048-1059
[42]   Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases [J].
Koh, Yen-Chun ;
Yang, Guliang ;
Lai, Ching-Shu ;
Weerawatanakorn, Monthana ;
Pan, Min-Hsiung .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (08)
[43]   Enhanced M1 and Impaired M2 Macrophage Polarization and Reduced Mitochondria! Biogenesis via Inhibition of AMP Kinase in Chronic Kidney Disease [J].
Li, Cong ;
Ding, Xiao Yan ;
Xiang, Dong Mei ;
Xu, Jie ;
Huang, Xiang Lan ;
Hou, Fan Fan ;
Zhou, Qiu Gen .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2015, 36 (01) :358-372
[44]   Regulatory Mechanism of lncRNAs in M1/M2 Macrophages Polarization in the Diseases of Different Etiology [J].
Jiang, Ping ;
Li, Xiaopeng .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[45]   Inhibition of M1 macrophage specific gene expression and promotion of M2 macrophage specific gene expression by bone mesenchymal stem cells [J].
Geng, Li-Xia ;
Yin, Xue-Hong ;
Li, Bai ;
Ding, Shi-Fang .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (01) :750-759
[46]   Reprint of: M1 macrophage-targeted curcumin nanocrystals with L-arginine-modified for acute lung injury by inhalation [J].
Wu, Shiyue ;
Guo, Pengchuan ;
Zhou, Qiren ;
Yang, Xiaowen ;
Dai, Jundong .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2025, 114 (01) :105-118
[47]   Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis [J].
Li, Hongxia ;
Cao, Zhiqiang ;
Liu, Chang ;
Wang, Yu ;
Wang, Lili ;
Tang, Yuhan ;
Yao, Ping .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (21) :12156-12170
[48]   Assessment of the Monocyte Subpopulations and M1/M2 Macrophage Ratio in Concentrated Bone Marrow Aspirate [J].
Butler, James J. ;
Dankert, John F. ;
Keller, Laura E. ;
Azam, Mohammad T. ;
Dahmen, Jari ;
Kerkhoffs, Gino M. M. J. ;
Kennedy, John G. .
CARTILAGE, 2024,
[49]   Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment [J].
Wang, Yi ;
Lin, Yao-Xin ;
Qiao, Sheng-Lin ;
An, Hong-Wei ;
Ma, Yang ;
Qiao, Zeng-Ying ;
Rajapaksha, R. P. Yeshan J. ;
Wang, Hao .
BIOMATERIALS, 2017, 112 :153-163
[50]   Increased macrophage M2/M1 ratio is associated with intracranial aneurysm rupture [J].
Stratilova, Maria Hundza ;
Koblizek, Miroslav ;
Steklacova, Anna ;
Benes, Vladimir ;
Sames, Martin ;
Hejcl, Ales ;
Zamecnik, Josef .
ACTA NEUROCHIRURGICA, 2023, 165 (01) :177-186
12345