M1/M2 macrophage-targeted nanotechnology and PROTAC for the treatment of atherosclerosis

被引：4
|
作者：
Ma, Yupeng [1 ,2 ]
Yang, Xiaofan [1 ,2 ]
Ning, Ke [1 ,2 ]
Guo, Haidong [1 ,2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Sch Integrat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Sch Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
来源：
LIFE SCIENCES | 2024年 / 352卷
基金：
中国国家自然科学基金;
关键词：
Atherosclerosis; Macrophage; Nanotechnology; PROTAC; CERIUM OXIDE NANOPARTICLES; ENDOPLASMIC-RETICULUM STRESS; TIO2; NANOPARTICLES; IN-VIVO; ANTIINFLAMMATORY PROPERTIES; INTRAPLAQUE HEMORRHAGE; M2; MACROPHAGES; POLARIZATION; INFLAMMATION; APOPTOSIS;
D O I：
10.1016/j.lfs.2024.122811
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Macrophages play key roles in atherosclerosis progression, and an imbalance in M1/M2 macrophages leads to unstable plaques; therefore, M1/M2 macrophage polarization-targeted treatments may serve as a new approach in the treatment of atherosclerosis. At present, there is little research on M1/M2 macrophage polarizationtargeted nanotechnology. Proteolysis-targeting chimera (PROTAC) technology, a targeted protein degradation technology, mediates the degradation of target proteins and has been widely promoted in preclinical and clinical applications as a novel therapeutic modality. This review summarizes the recent studies on M1/M2 macrophage polarization-targeted nanotechnology, focusing on the mechanism and advantages of PROTACs in M1/M2 macrophage polarization as a new approach for the treatment of atherosclerosis.
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页数：11
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