Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism

被引：31

作者：

Bu, Tong ^{[1
]}

Sun, Ziyan ^{[1
]}

Pan, Yi ^{[1
]}

Deng, Xia ^{[1
]}

Yuan, Guoyue ^{[1
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Dept Endocrinol, Zhenjiang 212001, Peoples R China

来源：

DIABETES & METABOLISM JOURNAL | 2024年 / 48卷 / 03期

关键词：

Adipose tissue; Glucagon-like peptide 1; Lipid metabolism; Non-alcoholic fatty liver disease; Obesity; BROWN ADIPOSE-TISSUE; GLP-1 RECEPTOR AGONIST; GCGR DUAL-AGONIST; GLUCOSE-TOLERANCE; INSULIN-SECRETION; HEPATIC STEATOSIS; DIFFERENTIATION; INCRETIN; OBESITY; CELLS;

D O I：

10.4093/dmj.2023.0277

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon-like peptide -1 (GLP-1) is a 30 -amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus. In recent years, basic and clinical studies have shown that GLP-1 is closely related to lipid metabolism, and it can participate in lipid metabolism by inhibiting fat synthesis, promoting fat differentiation, enhancing cholesterol metabolism, and promoting adipose browning. GLP-1 plays a key role in the occurrence and development of metabolic diseases such as obesity, nonalcoholic fatty liver disease, and atherosclerosis by regulating lipid metabolism. It is expected to become a new target for the treatment of metabolic disorders. The effects of GLP-1 and dual agonists on lipid metabolism also provide a more complete treatment plan for metabolic diseases. This article reviews the recent research progress of GLP-1 in lipid metabolism.

引用

页码：354 / 372

页数：20

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