The health benefits of dietary polyphenols on pediatric intestinal diseases: Mechanism of action, clinical evidence and future research progress

Pediatric intestinal development is immature, vulnerable to external influences and produce a variety of intestinal diseases. At present, breakthroughs have been made in the treatment of pediatric intestinal diseases, but there are still many challenges, such as toxic side effects, drug resistance, and the lack of more effective treatments and specific drugs. In recent years, dietary polyphenols derived from plants have become a research hotspot in the treatment of pediatric intestinal diseases due to their outstanding pharmacological activities such, as anti-inflammatory, antibacterial, antioxidant and regulation of intestinal flora. This article reviewed the mechanism of action and clinical evidence of dietary polyphenols in the treatment of pediatric intestinal diseases, and discussed the influence of physiological characteristics of children on the efficacy of polyphenols, and finally prospected the new dosage forms of polyphenols in pediatrics. Pediatric intestinal diseases pose significant challenges due to immature intestinal development, making them vulnerable to various external factors. Although there have been breakthroughs in treatment, challenges such as toxic side effects and drug resistance remain. Plant-derived dietary polyphenols are promising due to their anti-inflammatory, antibacterial and antioxidant properties. This review examines their mechanisms of action, clinical evidence, and potential new dosage forms for the treatment of pediatric intestinal diseases, taking into account the physiological characteristics of children. image