High frequency repetitive sensory stimulation improves temporal discrimination in healthy subjects

被引:20
作者
Erro, Roberto [1 ,2 ]
Rocchi, Lorenzo [1 ,3 ]
Antelmi, Elena [1 ,4 ]
Palladino, Raffaele [5 ]
Tinazzi, Michele [2 ]
Rothwell, John [1 ]
Bhatia, Kailash P. [1 ]
机构
[1] UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
[2] Univ Verona, Dipartimento Sci Neurol & Movimento, I-37100 Verona, Italy
[3] Univ Roma La Sapienza, Dept Neurol & Psychiat, I-00185 Rome, Italy
[4] Univ Bologna, Alma Mater Studiorum, Dept Biomed & Neuromotor Sci, Bologna, Italy
[5] Univ London Imperial Coll Sci Technol & Med, Dept Primary Care & Publ Hlth, London SW7 2AZ, England
关键词
Repetitive sensory stimulation; Coactivation; Plasticity; Somatosensory temporal discrimination; Dystonia; THRESHOLDS; PLASTICITY; NETWORKS; AGE;
D O I
10.1016/j.clinph.2015.06.023
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: High frequency electrical stimulation of an area of skin on a finger improves two-point spatial discrimination in the stimulated area, likely depending on plastic changes in the somatosensory cortex. However, it is unknown whether improvement also applies to temporal discrimination. Methods: Twelve young and ten elderly volunteers underwent the stimulation protocol onto the palmar skin of the right index finger. Somatosensory temporal discrimination threshold (STDT) was evaluated before and immediately after stimulation as well as 2.5 h and 24 h later. Results: There was a significant reduction in somatosensory temporal threshold only on the stimulated finger. The effect was reversible, with STDT returning to the baseline values within 24 h, and was smaller in the elderly than in the young participants. Conclusions: High frequency stimulation of the skin focally improves temporal discrimination in the area of stimulation. Given previous suggestions that the perceptual effects rely on plastic changes in the somatosensory cortex, our results are consistent with the idea that the timing of sensory stimuli is, at least partially, encoded in the primary somatosensory cortex. Significance: Such a protocol could potentially be used as a therapeutic intervention to ameliorate physiological decline in the elderly or in other disorders of sensorimotor integration. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:817 / 820
页数:4
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