Correlation between myelin basic protein levels in cerebrospinal fluid and motor speed in patients with schizophrenia

被引:3
作者
Enokida, Takako [1 ,2 ]
Hattori, Kotaro [1 ,3 ]
Ota, Miho [4 ,5 ]
Tatsumi, Megumi [1 ]
Hidese, Shinsuke [6 ]
Sato, Noriko [4 ]
Hoshino, Mikio [2 ,7 ]
Kunugi, Hiroshi [3 ,6 ]
机构
[1] Natl Ctr Neurol & Psychiat, Dept Bioresources, Med Genome Ctr, 4-1-1 Ogawahigashi, Tokyo 1878502, Japan
[2] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept NCNP Brain Funct & Pathol, Tokyo, Japan
[3] Natl Inst Neurosci, Natl Ctr Neurol & Psychiat, Dept Mental Disorder Res, Tokyo, Japan
[4] Natl Ctr Hosp Neurol & Psychiat, Dept Radiol, Tokyo, Japan
[5] Univ Tsukuba, Dept Neuropsychiat, Tsukuba, Japan
[6] Teikyo Univ, Sch Med, Dept Psychiat, Tokyo, Japan
[7] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Biochem & Cellular Biol, Tokyo, Japan
关键词
cerebrospinal fluid; demyelination; motor speed; myelin basic protein; schizophrenia; NEURON-SPECIFIC ENOLASE; MAJOR PSYCHIATRIC-DISORDERS; VOXEL-BASED MORPHOMETRY; WHITE-MATTER INTEGRITY; DEPRESSIVE DISORDER; COGNITIVE DEFICITS; PREFRONTAL CORTEX; JAPANESE VERSION; BRAIN; AGE;
D O I
10.1002/npr2.12471
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alterations in the white matter have been implicated in schizophrenia. Myelin basic protein (MBP), a component of the myelin sheath, in the cerebrospinal fluid (CSF) has been suggested as a biomarker for white matter damage in demyelinating diseases. This prompted us to examine the CSF-MBP levels in patients with schizophrenia. We analyzed the CSF-MBP levels in 152 patients with schizophrenia and 117 age- and sex-matched controls. A significant positive correlation between age and CSF-MBP levels was observed both in the patients (p < 0.001) and controls (p = 0.014). No significant difference was observed in the CSF-MBP levels between the two groups. However, among a subsample of the patients (N = 32), a significantly negative correlation was observed between CSF-MBP and age-adjusted motor speed score of the brief assessment of cognition in schizophrenia (rho = -0.59, p < 0.001). Further, among patients who underwent diffusional magnetic resonance imaging of the brain (N = 27), the CSF-MBP levels showed a significantly negative correlation with the mean kurtosis value in the right temporo-parietal region (p < 0.001). Our results suggest that the CSF-MBP level has limited utility as a diagnostic marker; however, higher CSF-MBP levels are associated with poorer motor speed, which may be associated with regional white matter damage in the brain in patients with schizophrenia.
引用
收藏
页码:663 / 670
页数:8
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