Immunocytes interact directly with cancer cells in the tumor microenvironment: one coin with two sides and future perspectives

被引:3
作者
Ye, Zhiyi [1 ]
Cheng, Pu [2 ]
Huang, Qi [3 ,4 ]
Hu, Jingjing [5 ]
Huang, Liming [1 ]
Hu, Guoming [6 ,7 ]
机构
[1] Zhejiang Univ, Shaoxing Hosp, Shaoxing Peoples Hosp, Dept Gen Surg Breast & Thyroid Surg,Sch Med, Shaoxing, Zhejiang, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gynecol, Hangzhou, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 2, Dept Oncol, Hefei, Anhui, Peoples R China
[4] Anhui Med Univ, Dept Oncol, Hefei, Anhui, Peoples R China
[5] Shaoxing Univ, Sch Med, Shaoxing, Zhejiang, Peoples R China
[6] Zhejiang Univ, Shaoxing Hosp, Shaoxing Peoples Hosp, Dept Gen Surg Breast & Thyroid Surg,Sch Med, Shaoxing, Zhejiang, Peoples R China
[7] Minist Educ, Key Lab Canc Prevent & Intervent, Hangzhou, Zhejiang, Peoples R China
关键词
immunocytes; cancer cells; direct and dual effect; tumor microenvironment; solid tumor; APOPTOSIS-INDUCING LIGAND; CYTOTOXIC T-LYMPHOCYTES; BREAST-CANCER; TNF-ALPHA; NECROSIS-FACTOR; TH9; CELLS; HEPATOCELLULAR-CARCINOMA; PROMOTES ANGIOGENESIS; MACROPHAGE POLARITY; ANTITUMOR-ACTIVITY;
D O I
10.3389/fimmu.2024.1388176
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The tumor microenvironment is closely linked to the initiation, promotion, and progression of solid tumors. Among its constitutions, immunologic cells emerge as critical players, facilitating immune evasion and tumor progression. Apart from their indirect impact on anti-tumor immunity, immunocytes directly influence neoplastic cells, either bolstering or impeding tumor advancement. However, current therapeutic modalities aimed at alleviating immunosuppression from regulatory cells on effector immune cell populations may not consistently yield satisfactory results in various solid tumors, such as breast carcinoma, colorectal cancer, etc. Therefore, this review outlines and summarizes the direct, dualistic effects of immunocytes such as T cells, innate lymphoid cells, B cells, eosinophils, and tumor-associated macrophages on tumor cells within the tumor microenvironment. The review also delves into the underlying mechanisms involved and presents the outcomes of clinical trials based on these direct effects, aiming to propose innovative and efficacious therapeutic strategies for addressing solid tumors.
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页数:16
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