The impact of nicotine smoking on spondyloarthritis and rheumatoid arthritis
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作者:
El Hasbani, G.
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Hartford HealthCare St Vincents Med Ctr, Dept Med, Bridgeport, CT 06606 USAHartford HealthCare St Vincents Med Ctr, Dept Med, Bridgeport, CT 06606 USA
El Hasbani, G.
[1
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Nassar, J. E.
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机构:
Amer Univ Beirut, Fac Med, Beirut, LebanonHartford HealthCare St Vincents Med Ctr, Dept Med, Bridgeport, CT 06606 USA
Nassar, J. E.
[2
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Ali, A. M. Elsayed
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Amer Univ Beirut, Fac Med, Beirut, LebanonHartford HealthCare St Vincents Med Ctr, Dept Med, Bridgeport, CT 06606 USA
Ali, A. M. Elsayed
[2
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Uthman, I.
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Amer Univ Beirut, Dept Internal Med, Med Ctr, Beirut, LebanonHartford HealthCare St Vincents Med Ctr, Dept Med, Bridgeport, CT 06606 USA
Uthman, I.
[3
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Jawad, A.
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Royal London Hosp, Dept Rheumatol, London, EnglandHartford HealthCare St Vincents Med Ctr, Dept Med, Bridgeport, CT 06606 USA
Jawad, A.
[4
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机构:
[1] Hartford HealthCare St Vincents Med Ctr, Dept Med, Bridgeport, CT 06606 USA
Objective. Nicotine has major side effects on human health through numerous mechanisms, one of which is the alteration of the immune system and its genetic components. Such alteration can be a predisposing factor for autoimmune diseases such as spondyloarthritis (SpA) and rheumatoid arthritis (RA). This review aims to shed light on the effects of nicotine smoking on the pathophysiology, clinical presentation, and management of SpA and RA. Methods. This review looked into the studies, excluding case reports and series, which were cited by PubMed/MEDLINE. Results. Patients with established autoimmune conditions may have a different underlying pathophysiology and disease course when exposed to nicotine through cigarette smoking. Through the involvement of several cytokines, endothelial dysfunction, and epigenetic mechanisms, the severity of SpA is more prominent in smokers. The global health status, pain, and fatigue are worse in SpA patients. The evidence on the effect of nicotine smoking on the treatment of SpA is still limited. Nicotine can contribute to RA via the disruption of cellular regulatory activity, inflammatory responses, morphological, physiological, biochemical, and enzymatic responses. As such, smokers with RA have higher disease activity and are more likely to be seropositive through the citrullination of peptides. In addition, these patients are at risk of achieving a suboptimal response to tumor necrosis factor inhibitors. Conclusions. Cigarette smoking can substantially affect the pathophysiology and clinical presentation of patients with SpA and RA. The impact of nicotine on the management of these diseases still needs to be further studied.
机构:
Harvard Med Sch, Joslin Diabet Ctr, Sect Immunobiol, One Joslin Pl, Boston, MA 02215 USA
RIKEN, Ctr Integrat Med Sci, Lab Stat & Translat Genet, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, JapanHarvard Med Sch, Joslin Diabet Ctr, Sect Immunobiol, One Joslin Pl, Boston, MA 02215 USA