Biopolymer patches for the simultaneous incorporation of local anesthetic and anti-inflammatory drugs

被引：0

作者：

Okolisan, Dorinel ^{[1
]}

Vlase, Titus ^{[1
,2
]}

Vlase, Gabriela ^{[1
,2
]}

Bradu, Ionela-Amalia ^{[1
,2
]}

Pahomi, Alexandru ^{[1
]}

Matichescu, Anamaria ^{[3
]}

机构：

[1] West Univ Timisoara, Res Ctr Thermal Anal Environm Problems, Pestalozzi St 16, Timisoara 300115, Romania

[2] West Univ Timisoara, ICAM Adv Environm Res Inst, Oituz 4, Timisoara, Romania

[3] Univ Med & Farm Timisoara, Fac Dent Med, Dept Prevent Community Dent & Oral Hlth, Spl Tudor Vladimirescu 14A, Timisoara 300173, Romania

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2024年

关键词：

Patches; Biopolymers; Amide anesthetics; Transdermal drug delivery; Galactan; Hydroxyethyl cellulose; Anti-inflammatory drugs; CARRAGEENAN; DELIVERY;

D O I：

10.1007/s10973-024-13225-1

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

This study presents a novel type of biopolymer patches in which anti-inflammatory drugs and amide-type anesthetics were simultaneously incorporated. Since the biopolymer matrix is composed of k-carrageenan, hydroxyethyl cellulose, and glycerol, as a plasticizer, the resulting patches have an elasticity and a "stickiness" that can be exploited in the field of transdermal delivery of drugs. Combinations of anesthetic and anti-inflammatory drugs resulted in twenty patches with a unique and distinct physical appearance. Furthermore, as indicated by FTIR, TG/DTG, and DSC analysis data, none of the active substances affects the integrity of the biopolymer matrix; instead, they influence the T melting of the patch matrix, either in its value increase or decrease.

引用

页数：15

共 38 条

[1] Chromatographic analysis of local anesthetics in biological samples [J].