Prevention and Treatment of Oral Mucositis in Pediatric Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials

被引：1

作者：

Andriakopoulou, Chrysi Stefania ^{[1
,5
]}

Yapijakis, Christos ^{[1
,2
]}

Koutelekos, Ioannis ^{[3
]}

Perdikaris, Pantelis ^{[4
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Agia Sophia Childrens Hosp, Sch Med, Dept Pediat 1, Athens, Greece

[2] Univ Res Inst Maternal & Child Hlth & Precis Med, Natl & Kapodistrian Univ Athens, Sch Med, Unit Orofacial Genet, Athens, Greece

[3] Univ West Attica, Sch Hlth & Care Sci, Dept Nursing, Athens, Greece

[4] Univ Peloponnese, Sch Hlth Sci, Dept Nursing, Tripolis, Greece

[5] Fedonos 21 Str, Dafni 17236, Athens, Greece

来源：

IN VIVO | 2024年 / 38卷 / 03期

关键词：

Oral mucositis; cancer; children; meta-analysis; review; LEVEL LASER THERAPY; CHEMOTHERAPY-INDUCED MUCOSITIS; ACUTE LYMPHOBLASTIC-LEUKEMIA; DOUBLE-BLIND; CHEWING GUM; NECK-CANCER; VITAMIN-E; CHILDREN; CHILDHOOD; RADIOTHERAPY;

D O I：

10.21873/invivo.13535

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Oral mucositis (OM) is a common and serious side effect of cancer treatment. The incidence of chemotherapy-induced OM in pediatric patients can reach up to 91.5% and has a major impact on patients' quality of life. The aim of the study was to assess the efficacy of current interventions and agents for the management of OM in children undergoing chemo/radiotherapy or hematopoietic stem cell transplantation (HSCT). Materials and Methods: A systematic search of randomized controlled trials (RCTs) was conducted in the MEDLINE and Scopus databases from January 2000 until March 2023. Thirty-four randomized studies meeting the inclusion criteria were identified and five RCTs investigating the efficacy of Low Level Laser Therapy (LLLT) intervention or the agent honey were included in the meta-analysis. Results: The meta-analysis of two RCTs indicated that topical application of honey on oral mucosa was effective in shortening the mean duration of hospital stay in children with severe OM (MD=-4.33, p=0.002). However, LLLT was not found to be effective for the prevention or treatment of OM grade >= II (RR=0.99, p=0.99). Moreover, the

引用

页码：1016 / 1029

页数：14

共 62 条

[1] Honey and a Mixture of Honey, Beeswax, and Olive Oil-Propolis Extract in Treatment of Chemotherapy-Induced Oral Mucositis: A Randomized Controlled Pilot Study [J].