Therapeutic potential of grape pomace extracts: A review of scientific evidence

被引：19

作者：

Machado, Tatiane O. X. ^{[1
,2
,3
]}

Portugal, Isabella ^{[4
]}

Kodel, Helena de A. C. ^{[5
]}

Droppa-Almeida, Daniela ^{[5
]}

Lima, Marcos Dos Santos ^{[6
]}

Fathi, Faezeh ^{[7
]}

Oliveira, M. Beatriz P. P. ^{[8
]}

de Albuquerque-Junior, Ricardo L. C. ^{[8
]}

Dariva, Claudio ^{[5
]}

Souto, Eliana B. ^{[1
,9
]}

机构：

[1] Univ Porto, Lab Pharmaceut Technol, Fac Pharm, P-4050313 Porto, Portugal

[2] Univ Tiradentes, Rede Nordeste Biotecnol RENORBIO, BR-49010390 Aracaju, SE, Brazil

[3] Fed Inst Sertao Pernambucano, Dept Agroind, Campus Petrolina Zona Rural 647,Km 22,PISNC N4, BR-56302970 Petrolina, Brazil

[4] Cambridge Hlth Alliance, Dept Med, Cambridge, MA USA

[5] Univ Tiradentes, Inst Technol & Res, BR-49010390 Aracaju, SE, Brazil

[6] Fed Inst Sertao Pernambucano, Dept Food Technol, Campus Petrolina, BR-56316686 Petrolina, PE, Brazil

[7] Univ Porto, Fac Pharm, Dept Chem Sci, REQUIMTE LAQV, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[8] Univ Fed Santa Catarina, Hlth Sci Ctr, Dept Pathol, BR-86040900 Florianopolis, SC, Brazil

[9] Univ Porto, Fac Pharm, Dept Drug Sci, Lab Pharmaceut Technol, P-4050313 Porto, Portugal

来源：

FOOD BIOSCIENCE | 2024年 / 60卷

关键词：

Grape marc; Plant extract; Alzheimer's disease; Parkinson's disease; Antitumoral; PHENOLIC-COMPOUNDS; BY-PRODUCTS; IN-VITRO; ANTIOXIDANT; WHITE; RICH; RESVERATROL; POLYPHENOLS; BIOAVAILABILITY; ANTHOCYANINS;

D O I：

10.1016/j.fbio.2024.104210

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Grape pomace is widely studied as a source of phenolic compounds. These secondary metabolites are recognized by presenting pharmacological properties, such as antioxidant, antimicrobial, anti-tyrosinase, vasodilation, antiinflammatory, antihyperglycemic and antitumoral, that can be exploited in new and sustainable therapies. In this review, we gather scientific evidences of biological properties of extracts and individual phenolic from grape pomace through in vitro, in vivo or in silico studies. In a more specific approach, we discuss the mechanisms of action of these compounds as therapeutic agents to prevent or treat diabetes mellitus, cardiovascular and neurodegenerative diseases and cancer. The outcomes from the studies evaluated show that phenolic extracts from grape pomace have a high potential to be administrated as supplements and even to be incorporated in medicine formulations. However, even the researchers suggesting the mechanism of action responsible for their effects, the biological pathways are not completely elucidated. Furthermore, there is still a lack of in vivo studies to obtain more consistent evidences.

引用

页数：13

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