Neuroblastoma susceptibility and association of N7-methylguanosine modification gene polymorphisms: multi-center case-control study

被引：0
作者：
Lin, Huiran [1 ,2 ]
Liao, Fan [1 ]
Liu, Jiabin [1 ]
Yang, Zhonghua [3 ]
Zhang, Jiao [4 ]
Cheng, Jiwen [5 ]
Zhou, Haixia [6 ,7 ]
Li, Suhong [8 ]
Li, Li [9 ]
Li, Yong [10 ]
Zhuo, Zhenjian [11 ]
He, Jing [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Guangzhou Inst Pediat, Guangzhou Women & Childrens Med Ctr, Dept Pediat Surg,Guangdong Prov Key Lab Res Struct, Guangzhou 510623, Guangdong, Peoples R China
[2] Macau Univ Sci & Technol, Fac Med, Macau 999078, Peoples R China
[3] China Med Univ, Shengjing Hosp, Dept Pediat Surg, Shenyang 110004, Liaoning, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Pediat Surg, Zhengzhou 450052, Henan, Peoples R China
[5] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Pediat Surg, Xian 710004, Shaanxi, Peoples R China
[6] Wenzhou Med Univ, Affiliated Hosp 2, Dept Hematol, Key Lab Pediat Hematol & Oncol Dis Wenzhou, Wenzhou 325027, Zhejiang, Peoples R China
[7] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China
[8] Children Hosp & Women Hlth Ctr Shanxi, Dept Pathol, Taiyuan 030013, Shannxi, Peoples R China
[9] Kunming Childrens Hosp, Yunnan Inst Pediat Res, Yunnan Med Ctr Pediat Dis, Kunming Key Lab Children Infect & Immun,Key Lab Ch, Kunming 650228, Yunnan, Peoples R China
[10] Hunan Childrens Hosp, Dept Pediat Surg, Changsha 410004, Hunan, Peoples R China
[11] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Anim Ctr, Shenzhen 518055, Peoples R China
来源：
PEDIATRIC RESEARCH | 2025年 / 97卷 / 01期
基金：
中国国家自然科学基金;
关键词：
HIGH-RISK NEUROBLASTOMA; M(7)G; PREDISPOSITION; IDENTIFICATION; MUTATIONS; SURVIVAL; ALK;
D O I：
10.1038/s41390-024-03318-w
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
BackgroundNeuroblastoma (NB) is a common extracranial solid malignancy in children. The N7-methylguanosine (m7G) modification gene METTL1/WDR4 polymorphisms may serve as promising molecular markers for identifying populations susceptible to NB.MethodsTaqMan probes was usded to genotype METTL1/WDR4 single nucleotide polymorphisms (SNPs) in 898 NB patients and 1734 healthy controls. A logistic regression model was utilized to calculate the odds ratio (OR) and 95% confidence interval (CI), evaluating the association between genotype polymorphisms and NB susceptibility. The analysis was also stratified by age, sex, tumor origin site, and clinical stage.ResultsIndividual polymorphism of the METTL1/WDR4 gene investigated in this study did not show significant associations with NB susceptibility. However, combined genotype analysis revealed that carrying all 5 WDR4 protective genotypes was associated with a significantly lower NB risk compared to having 0-4 protective genotypes (AOR = 0.82, 95% CI = 0.69-0.96, P = 0.014). Further stratified analyses revealed that carrying 1-3 METTL1 risk genotypes, the WDR4 rs2156316 CG/GG genotype, the WDR4 rs2248490 CG/GG genotype, and having all five WDR4 protective genotypes were all significantly correlated with NB susceptibility in distinct subpopulations.ConclusionsIn conclusion, our findings suggest significant associations between m7G modification gene METTL1/WDR4 SNPs and NB susceptibility in specific populations.ImpactGenetic variation in m7G modification gene is associated with susceptibility to NB.Single nucleotide polymorphisms in are associated with susceptibility to NB.Single nucleotide polymorphisms of can be used as a biomarker for screening NB susceptible populations.
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收藏
页码：153 / 159
页数：7
相关论文
共 48 条
[1]   Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis [J].
Alcina, Antonio ;
Fedetz, Maria ;
Fernandez, Oscar ;
Saiz, Albert ;
Izquierdo, Guillermo ;
Lucas, Miguel ;
Leyva, Laura ;
Garcia-Leon, Juan-Antonio ;
del Mar Abad-Grau, Maria ;
Alloza, Iraide ;
Antigueedad, Alfredo ;
Garcia-Barcina, Maria J. ;
Vandenbroeck, Koen ;
Varade, Jezabel ;
de la Hera, Belen ;
Arroyo, Rafael ;
Comabella, Manuel ;
Montalban, Xavier ;
Petit-Marty, Natalia ;
Navarro, Arcadi ;
Otaegui, David ;
Olascoaga, Javier ;
Blanco, Yolanda ;
Urcelay, Elena ;
Matesanz, Fuencisla .
JOURNAL OF MEDICAL GENETICS, 2013, 50 (01) :25-33
[2]   Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA [J].
Alexandrov, A ;
Martzen, MR ;
Phizicky, EM .
RNA, 2002, 8 (10) :1253-1266
[3]   Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 [J].
Bahlo, Melanie ;
Booth, David R. ;
Broadley, Simon A. ;
Brown, Matthew A. ;
Foote, Simon J. ;
Griffiths, Lyn R. ;
Kilpatrick, Trevor J. ;
Lechner-Scott, Jeanette ;
Moscato, Pablo ;
Perreau, Victoria M. ;
Rubio, Justin P. ;
Scott, Rodney J. ;
Stankovich, Jim ;
Stewart, Graeme J. ;
Taylor, Bruce V. ;
Wiley, James ;
Clarke, Glynnis ;
Cox, Mathew B. ;
Csurhes, Peter A. ;
Danoy, Patrick ;
Drysdale, Karen ;
Field, Judith ;
Foote, Simon J. ;
Greer, Judith M. ;
Guru, Preethi ;
Hadler, Johanna ;
McMorran, Brendan J. ;
Jensen, Cathy J. ;
Johnson, Laura J. ;
McCallum, Ruth ;
Merriman, Marilyn ;
Merriman, Tony ;
Pryce, Karen ;
Tajouri, Lotfi ;
Wilkins, Ella J. ;
Browning, Brian L. ;
Browning, Sharon R. ;
Perera, Devindri ;
Butzkueven, Helmut ;
Carroll, William M. ;
Chapman, Caron ;
Kermode, Allan G. ;
Marriott, Mark ;
Mason, Deborah ;
Heard, Robert N. ;
Pender, Michael P. ;
Slee, Mark ;
Tubridy, Niall ;
Willoughby, Ernest .
NATURE GENETICS, 2009, 41 (07) :824-U84
[4]   Down Syndrome [J].
Bull, Marilyn J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (24) :2344-2352
[5]   Common variations in BARD1 influence susceptibility to high-risk neuroblastoma [J].
Capasso, Mario ;
Devoto, Marcella ;
Hou, Cuiping ;
Asgharzadeh, Shahab ;
Glessner, Joseph T. ;
Attiyeh, Edward F. ;
Mosse, Yael P. ;
Kim, Cecilia ;
Diskin, Sharon J. ;
Cole, Kristina A. ;
Bosse, Kristopher ;
Diamond, Maura ;
Laudenslager, Marci ;
Winter, Cynthia ;
Bradfield, Jonathan P. ;
Scott, Richard H. ;
Jagannathan, Jayanti ;
Garris, Maria ;
McConville, Carmel ;
London, Wendy B. ;
Seeger, Robert C. ;
Grant, Struan F. A. ;
Li, Hongzhe ;
Rahman, Nazneen ;
Rappaport, Eric ;
Hakonarson, Hakon ;
Maris, John M. .
NATURE GENETICS, 2009, 41 (06) :718-723
[6]   METTL1 promotes hepatocarcinogenesis via m7G tRNA modification-dependent translation control [J].
Chen, Zhihang ;
Zhu, Wanjie ;
Zhu, Shenghua ;
Sun, Kaiyu ;
Liao, Junbin ;
Liu, Haining ;
Dai, Zihao ;
Han, Hui ;
Ren, Xuxin ;
Yang, Qingxia ;
Zheng, Siyi ;
Peng, Baogang ;
Peng, Sui ;
Kuang, Ming ;
Lin, Shuibin .
CLINICAL AND TRANSLATIONAL MEDICINE, 2021, 11 (12)
[7]   Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials [J].
Cheng, Yuan ;
He, Cai ;
Wang, Manni ;
Ma, Xuelei ;
Mo, Fei ;
Yang, Shengyong ;
Han, Junhong ;
Wei, Xiawei .
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2019, 4 (1)
[8]   Neuroblastoma: developmental biology, cancer genomics and immunotherapy [J].
Cheung, Nai-Kong V. ;
Dyer, Michael A. .
NATURE REVIEWS CANCER, 2013, 13 (06) :397-411
[9]   METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development [J].
Deng, Yujie ;
Zhou, Zhongyang ;
Ji, Weidong ;
Lin, Shuibin ;
Wang, Min .
STEM CELL RESEARCH & THERAPY, 2020, 11 (01)
[10]   Copy number variation at 1q21.1 associated with neuroblastoma [J].
Diskin, Sharon J. ;
Hou, Cuiping ;
Glessner, Joseph T. ;
Attiyeh, Edward F. ;
Laudenslager, Marci ;
Bosse, Kristopher ;
Cole, Kristina ;
Mosse, Yael P. ;
Wood, Andrew ;
Lynch, Jill E. ;
Pecor, Katlyn ;
Diamond, Maura ;
Winter, Cynthia ;
Wang, Kai ;
Kim, Cecilia ;
Geiger, Elizabeth A. ;
McGrady, Patrick W. ;
Blakemore, Alexandra I. F. ;
London, Wendy B. ;
Shaikh, Tamim H. ;
Bradfield, Jonathan ;
Grant, Struan F. A. ;
Li, Hongzhe ;
Devoto, Marcella ;
Rappaport, Eric R. ;
Hakonarson, Hakon ;
Maris, John M. .
NATURE, 2009, 459 (7249) :987-U112
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