Bariatric surgical procedures such as sleeve gastrectomy (SG) provide effective type 2 diabetes (T2D) remission in human patients. Previous work demonstrated that gastrointestinal levels of the bacterial metabolite lithocholic acid (LCA) are decreased after SG in mice and humans. Here, we show that LCA worsens glucose tolerance and impairs whole-body metabolism. We also show that taurodeoxycholic acid (TDCA), which is the only bile acid whose concentration increases in the murine small intestine post-SG, suppresses the bacterial bile acid-inducible ( bai ) operon and production of LCA both in vitro and in vivo. . Treatment of diet- induced obese mice with TDCA reduces LCA levels and leads to microbiome-dependent improvements in glucose handling. Moreover, TDCA abundance is decreased in small intestinal tissue from T2D patients. This work reveals that TDCA is an endogenous inhibitor of LCA production and suggests that TDCA may contribute to the glucoregulatory effects of bariatric surgery.
机构:
Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Devendran, Saravanan
Shrestha, Rachana
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Shrestha, Rachana
Alves, Joao M. P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo, BrazilCarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Alves, Joao M. P.
Wolf, Patricia G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Wolf, Patricia G.
Ly, Lindsey
论文数: 0引用数: 0
h-index: 0
机构:
Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Ly, Lindsey
Hernandez, Alvaro G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Keck Ctr Biotechnol, Urbana, IL USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Hernandez, Alvaro G.
Mendez-Garcia, Celia
论文数: 0引用数: 0
h-index: 0
机构:Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Mendez-Garcia, Celia
Inboden, Ashley
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Inboden, Ashley
Wiley, J'nai
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Wiley, J'nai
Paul, Oindrila
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Paul, Oindrila
Allen, Avery
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Allen, Avery
Springer, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Springer, Emily
Wright, Chris L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Wright, Chris L.
Fields, Christopher J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Fields, Christopher J.
Daniel, Steven L.
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Daniel, Steven L.
Ridlon, Jason M.
论文数: 0引用数: 0
h-index: 0
机构:
Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Univ Illinois, Canc Ctr Illinois, Urbana, IL 61801 USA
Virginia Commonwealth Univ, Sch Med, Dept Microbiol & Immunol, Richmond, VA 23298 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Dutia, R.
Embrey, M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Embrey, M.
O'Brien, S.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
O'Brien, S.
Haeusler, R. A.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Haeusler, R. A.
Agenor, K. K.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Agenor, K. K.
Homel, P.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Med, New York, NY USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Homel, P.
McGinty, J.
论文数: 0引用数: 0
h-index: 0
机构:
St Lukes Roosevelt Hosp, Dept Surg, Div Bariatr & Minimally Invas Surg, New York, NY 10025 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
McGinty, J.
Vincent, R. P.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll Hosp NHS Fdn Trust Denmark Hill, Dept Clin Biochem, London, EnglandColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Vincent, R. P.
Alaghband-Zadeh, J.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn, Dept Clin Biochem, London, EnglandColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Alaghband-Zadeh, J.
Staels, B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, INSERM, Inst Pasteur Lille, EGID,UMR 1011, Lille, FranceColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Staels, B.
le Roux, C. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Coll Dublin, Diabetes Complicat Res Ctr, Conway Inst, Dublin 2, IrelandColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
le Roux, C. W.
Yu, J.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Yu, J.
Laferrere, B.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USA
Daiichi Sankyo RD Novare Co Ltd, Translat Res Dept, Tokyo, JapanStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Funabashi, Masanori
Grove, Tyler L.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Grove, Tyler L.
Wang, Min
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Wang, Min
Varma, Yug
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Varma, Yug
McFadden, Molly E.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Chem, Bloomington, IN USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
McFadden, Molly E.
Brown, Laura C.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Chem, Bloomington, IN USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Brown, Laura C.
Guo, Chunjun
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Guo, Chunjun
Higginbottom, Steven
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Higginbottom, Steven
Almo, Steven C.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Almo, Steven C.
Fischbach, Michael A.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USA
Chan Zuckerberg Biohub, San Francisco, CA 94158 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
机构:
Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Devendran, Saravanan
Shrestha, Rachana
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Shrestha, Rachana
Alves, Joao M. P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo, BrazilCarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Alves, Joao M. P.
Wolf, Patricia G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Wolf, Patricia G.
Ly, Lindsey
论文数: 0引用数: 0
h-index: 0
机构:
Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Ly, Lindsey
Hernandez, Alvaro G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Keck Ctr Biotechnol, Urbana, IL USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Hernandez, Alvaro G.
Mendez-Garcia, Celia
论文数: 0引用数: 0
h-index: 0
机构:Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Mendez-Garcia, Celia
Inboden, Ashley
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Inboden, Ashley
Wiley, J'nai
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Wiley, J'nai
Paul, Oindrila
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Paul, Oindrila
Allen, Avery
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Allen, Avery
Springer, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Springer, Emily
Wright, Chris L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Wright, Chris L.
Fields, Christopher J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Fields, Christopher J.
Daniel, Steven L.
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Daniel, Steven L.
Ridlon, Jason M.
论文数: 0引用数: 0
h-index: 0
机构:
Carl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Univ Illinois, Canc Ctr Illinois, Urbana, IL 61801 USA
Virginia Commonwealth Univ, Sch Med, Dept Microbiol & Immunol, Richmond, VA 23298 USACarl R Woese Inst Genom Biol, Microbiome Metab Engn Theme, Urbana, IL 61801 USA
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Dutia, R.
Embrey, M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Embrey, M.
O'Brien, S.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
O'Brien, S.
Haeusler, R. A.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Haeusler, R. A.
Agenor, K. K.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Agenor, K. K.
Homel, P.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Med, New York, NY USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Homel, P.
McGinty, J.
论文数: 0引用数: 0
h-index: 0
机构:
St Lukes Roosevelt Hosp, Dept Surg, Div Bariatr & Minimally Invas Surg, New York, NY 10025 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
McGinty, J.
Vincent, R. P.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll Hosp NHS Fdn Trust Denmark Hill, Dept Clin Biochem, London, EnglandColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Vincent, R. P.
Alaghband-Zadeh, J.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn, Dept Clin Biochem, London, EnglandColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Alaghband-Zadeh, J.
Staels, B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, INSERM, Inst Pasteur Lille, EGID,UMR 1011, Lille, FranceColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Staels, B.
le Roux, C. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Coll Dublin, Diabetes Complicat Res Ctr, Conway Inst, Dublin 2, IrelandColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
le Roux, C. W.
Yu, J.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
Yu, J.
Laferrere, B.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, New York Obes Res Ctr, Dept Med, New York, NY 10032 USA
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USA
Daiichi Sankyo RD Novare Co Ltd, Translat Res Dept, Tokyo, JapanStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Funabashi, Masanori
Grove, Tyler L.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Grove, Tyler L.
Wang, Min
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Wang, Min
Varma, Yug
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Varma, Yug
McFadden, Molly E.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Chem, Bloomington, IN USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
McFadden, Molly E.
Brown, Laura C.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Chem, Bloomington, IN USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Brown, Laura C.
Guo, Chunjun
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Guo, Chunjun
Higginbottom, Steven
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Higginbottom, Steven
Almo, Steven C.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Almo, Steven C.
Fischbach, Michael A.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
Stanford Univ, ChEM H, Stanford, CA 94305 USA
Chan Zuckerberg Biohub, San Francisco, CA 94158 USAStanford Univ, Dept Bioengn, Stanford, CA 94305 USA