Synthesis of Diverse Allylic Sulfone Derivatives via Sequential Hydroalkoxylation of 1,3-Enynes

被引：0
|
作者：
Kumar, Sourav [1 ,2 ]
Shah, Bhahwal Ali [1 ,2 ]
机构：
[1] Acad Sci & Innovat Res AcSIR, Nat Prod & Med Chem, Ghaziabad 201002, India
[2] CSIR Indian Inst Integrat Med, Jammu 180001, India
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2024年 / 30卷 / 42期
关键词：
1,3-enyne; allylic sulfone; hydroalkoxylation; oxocarbenium cation; delta-hydroxylactone; ALLENES;
D O I：
10.1002/chem.202401049
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A first metal-free protocol for the synthesis of allylic sulfones featuring aldehyde functionality at the delta-position has been reported. The formation of structurally complex delta,delta-dimethoxy allylic sulfones is enabled by the direct nucleophilic attack of methoxide onto the sulfone-containing 1,3-enynes. The present approach allows facile installation of acetal groups within the allylic sulfone scaffold, providing versatile platforms for further functionalization and drug development.
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页数：7
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