En Face and Volumetric Comparison of Hypertransmission Defects Evaluated by Cirrus and Spectralis Optical Coherence Tomography

center dot PURPOSE: To evaluate and compare en face and 3dimensional (3-D) properties of hypertransmission defects (HTDs) between different optical coherence tomography (OCT) devices using OCT volumes and reconstructed en face images. center dot SETTINGS: Comparative diagnostic evaluation study. center dot METHODS: Thirty eyes with dry age -related macular degeneration (AMD) that underwent dense OCT macular volume scans with both the Spectralis (97 Bscans/volume; 2910 B -scans in total) and Cirrus OCT (128 B-scans/volume; 3840 B -scans in total) from the Amish Eye Study cohort were included in this analysis. HTD regions were labeled on each B -scan and reconstructed into en face and 3-D volume images. Properties of HTD volume were compared between the 2 devices. center dot RESULTS: The qualitative score of en face images for HTD was higher for the Cirrus compared to the Spectralis ( P < .01). The quality of Spectralis en face images improved after preprocessing and reconstruction. The 2D HTD area on en face obtained from 2-D projections of 3-D volume did not differ between devices ( P = .478, ICC = 0.998; Jaccard index 0.721 +/- 0.086). There was no difference in the number, volume, PALs, and surface areas of HTDs between devices in the volumetric analysis (all P >= .090). The signal intensity of HTD normalized by the mean choroidal signal intensity did not differ between devices ( P = .861). center dot CONCLUSIONS: The visualization of HTD on en face images from Spectralis OCT could be enhanced through image processing. The equivalence in 3-D HTD parameters between the 2 devices suggests interchangeability for assessing these lesions in AMD. (Am J Ophthal mol 2024;264: 135-144. (c) 2024 Elsevier Inc. All rights reserved.)