Use of murine models for the study of obstructive sleep apnea syndrome in Down syndrome

被引：0
作者：
Moreau, M. [1 ]
Madani, A. [2 ,5 ]
Dard, R. [1 ]
Bourgeois, T. [2 ]
d'Ortho, M. -P [2 ,3 ]
Delclaux, C. [2 ,4 ]
Janel, N. [1 ]
Matrot, B. [2 ]
机构：
[1] Univ Paris Cite, CNRS, BFA, UMR 8251, F-75013 Paris, France
[2] Univ Paris Cite, NeuroDiderot, Inserm, F-75019 Paris, France
[3] Hop Bichat Claude Bernard, AP HP, Serv physiol explorat fonct, F-75018 Paris, France
[4] Hop Robert Debre, AP HP, Serv explorat fonct Pediat, F-75019 Paris, France
[5] Hop Robert Debre, NeuroDiderot, Inserm, 48 Blvd Serurier, F-75019 Paris, France
来源：
REVUE DES MALADIES RESPIRATOIRES | 2024年 / 41卷 / 04期
关键词：
Down syndrome; Obstructive sleep apnea syndrome; Murine models; CHILDREN;
D O I：
10.1016/j.rmr.2024.02.010
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Down syndrome (DS), or trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21, leading to various characteristic physical features as well as developmental and cognitive delays. Obstructive sleep apnea syndrome (OSAS) is a common disorder in both adult and pediatric patients with DS. Several characteristics of DS may contribute to the development or worsening of OSAS. Numerous murine models of DS exist. A number of studies have explored apneas and the risk of upper airway obstruction in these models, but up until now, only in adulthood. (c) 2024 SPLF. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：279 / 282
页数：4
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