Exploiting pancreatic cancer metabolism:challenges and opportunities

被引：10
作者：
De Santis, Maria Chiara [1 ]
Bockorny, Bruno [2 ,3 ]
Hirsch, Emilio [1 ]
Cappello, Paola [1 ]
Martini, Miriam [1 ]
机构：
[1] Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy
[2] Harvard Med Sch, BIDMC Dept Med, Boston, MA USA
[3] Harvard Med Sch, Boston, MA USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2024年 / 30卷 / 06期
关键词：
DUCTAL ADENOCARCINOMA; ONCOGENIC KRAS; CELL; PHOSPHOINOSITIDES; GEMCITABINE; FOLFIRINOX; GLYCOLYSIS; EXPRESSION; AUTOPHAGY;
D O I：
10.1016/j.molmed.2024.03.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell functions and tumor growth. We also discuss ongoing clinical trials that explore metabolic modulation for PDAC, targeting mitochondrial metabolism, asparagine and glutamine addiction, and autophagy inhibition. Overcoming challenges in understanding nutrient effects on immune-stromal-tumor interactions holds promise for innovative therapeutic strategies.
引用
收藏
页码：592 / 604
页数：13
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