Hormone receptor-positive early breast cancer in young women: A comprehensive review

被引：4

作者：

Walbaum, Benjamin ^{[1
,2
,3
]}

Garcia-Fructuoso, Isabel ^{[1
,2
]}

Martinez-Saez, Olga ^{[1
,2
]}

Schettini, Francesco ^{[1
,2
]}

Sanchez, Cesar ^{[3
,4
]}

Acevedo, Francisco ^{[3
,4
]}

Chic, Nuria ^{[1
,2
]}

Munoz-Carrillo, Javier ^{[2
]}

Adamo, Barbara ^{[1
,2
]}

Munoz, Montserrat ^{[1
,2
,7
]}

Partridge, Ann H. ^{[5
,6
,7
]}

Bellet, Meritxell ^{[8
,9
]}

Braso-Maristany, Fara ^{[1
,10
,11
]}

Prat, Aleix ^{[1
,10
,11
,12
,13
]}

Vidal, Maria ^{[1
,2
,11
,12
,13
]}

机构：

[1] Hosp Clin Barcelona, August Pi I Sunyer Biomed Res Inst, Dept Med Oncol, Translat Genom & Targeted Therapies Solid Tumors G, Barcelona, Spain

[2] Hosp Clin Barcelona, Dept Med Oncol, Barcelona, Spain

[3] Pontificia Univ Catolica Chile, Dept Med Oncol, Santiago, Chile

[4] Univ Catolica Chile, Fac Med, Santiago, Chile

[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[6] Dana Farber Brigham Canc Ctr, Breast Oncol Program, Boston, MA USA

[7] Harvard Med Sch, Boston, MA USA

[8] Vall dHebron Univ Hosp, Oncol Dept, Breast Canc Unit, Barcelona, Spain

[9] Vall dHebron Inst Oncol, Barcelona, Spain

[10] Hosp Clin Barcelona, Inst Canc & Blood Disorders, Barcelona, Spain

[11] Reveal Genom, Barcelona, Spain

[12] Hosp Quironsalud, Inst Oncol IOB, Barcelona, Spain

[13] Univ Barcelona, Fac Med & Hlth Sci, Barcelona, Spain

来源：

CANCER TREATMENT REVIEWS | 2024年 / 129卷

关键词：

Young women; Early breast cancer; Hormone receptor-positive; Biomarkers; Prognosis; Genomic-signatures; INTERNATIONAL CONSENSUS GUIDELINES; ENDOCRINE THERAPY; PREMENOPAUSAL PATIENTS; FERTILITY PRESERVATION; ADJUVANT CHEMOTHERAPY; MOLECULAR PORTRAITS; OVARIAN SUPPRESSION; TAMOXIFEN; DIAGNOSIS; AGE;

D O I：

10.1016/j.ctrv.2024.102804

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of breast cancer in <= 40 yr-old women (YWBC) has been steadily increasing in recent decades. Although this group of patients represents less than 10 % of all newly diagnosed BC cases it encompasses a significant burden of disease. Usually underrepresented in clinical trials, YWBCs are also characterized by late diagnoses and poorly differentiated, aggressive-subtype disease, partly explaining its poor prognosis along with a high recurrence risk, and high mortality rates. On the other hand, YWBC treatment poses unique challenges such as preservation of fertility, and long-term toxicity and adverse events. Herein, we summarize the current evidence in hormone receptor-positive YWBC including specific risk factors, clinicopathologic and genomic features, and available evidence on response to chemotherapy and endocrine therapy. Overall, we advocate for a more comprehensive multidisciplinary healthcare model to improve the outcomes and the quality of life of this subset of younger patients.

引用

页数：12

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