Mosaic vaccine-induced antibody-dependent cellular phagocytosis associated with delayed HIV-1 viral load rebound post treatment interruption

被引：0

作者：

Mdluli, Thembi ^{[1
,2
]}

Slike, Bonnie M. ^{[1
,2
]}

Curtis, Daniel J. ^{[1
,2
]}

Shubin, Zhanna ^{[1
,2
,6
]}

Tran, Ursula ^{[1
,2
]}

Li, Yifan ^{[1
,2
]}

Dussupt, Vincent ^{[1
,2
]}

Mendez-Rivera, Letzibeth ^{[1
,2
]}

Pinyakorn, Suteeraporn ^{[1
,2
]}

Stieh, Daniel J. ^{[3
]}

Tomaka, Frank L. ^{[4
]}

Schuitemaker, Hanneke ^{[3
]}

Pau, Maria G. ^{[3
]}

Colby, Donn J. ^{[1
,2
,5
]}

Kroon, Eugene ^{[5
]}

Sacdalan, Carlo ^{[5
]}

de Souza, Mark ^{[5
]}

Phanupak, Nittaya ^{[5
]}

Hsu, Denise C. ^{[1
,2
]}

Ananworanich, Jintanat ^{[1
,2
]}

Ake, Julie A. ^{[1
]}

Trautmann, Lydie ^{[1
,2
]}

Vasan, Sandhya ^{[1
,2
]}

Robb, Merlin L. ^{[1
,2
]}

Krebs, Shelly J. ^{[1
]}

Paquin-Proulx, Dominic ^{[1
,2
]}

Rolland, Morgane ^{[1
,2
]}

机构：

[1] US Mil HIV Res Program MHRP, CIDR, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA

[2] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD 20817 USA

[3] Janssen Vaccines & Prevent BV, NL-2333 CN Leiden, Netherlands

[4] Janssen R&D US, Titusville, NJ USA

[5] Inst HIV Res & Innovat, SEARCH, Bangkok 10330, Thailand

[6] US FDA, Silver Spring, MD 20903 USA

来源：

CELL REPORTS | 2024年 / 43卷 / 06期

关键词：

ANTIRETROVIRAL THERAPY; PROTECTIVE EFFICACY; LATENT RESERVOIR; HIGH-THROUGHPUT; CHALLENGES; STABILITY;

D O I：

10.1016/j.celrep.2024.114344

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A heterologous Ad26/MVA vaccine was given prior to an analytic treatment interruption (ATI) in people living with HIV -1 (mainly CRF01_AE) who initiated antiretroviral treatment (ART) during acute HIV -1. We investigate the impact of Ad26/MVA vaccination on antibody (Ab)-mediated immune responses and their effect on time to viral rebound. The vaccine mainly triggers vaccine -matched binding Abs while, upon viral rebound post ATI, infection -specific CRF01_AE binding Abs increase in all participants. Binding Abs are not associated with time to viral rebound. The Ad26/MVA mosaic vaccine profile consists of correlated non-CRF01_AE binding Ab and Fc effector features, with strong Ab-dependent cellular phagocytosis (ADCP) responses. CRF01_AE-specific ADCP responses (measured either prior to or post ATI) are significantly higher in individuals with delayed viral rebound. Our results suggest that vaccines eliciting cross -reactive responses with circulating viruses in a target population could be beneficial and that ADCP responses may play a role in viral control post treatment interruption.

引用

页数：15

共 18 条

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