Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

被引：1

作者：

Rodriguez-Fernandez, Blanca ^{[1
,2
,3
,4
]}

Sanchez-Benavides, Gonzalo ^{[1
,2
,5
]}

Genius, Patricia ^{[1
,2
,3
]}

Minguillon, Carolina ^{[1
,2
,5
]}

Fauria, Karine ^{[1
,5
]}

De Vivo, Immaculata ^{[6
,7
]}

Navarro, Arcadi ^{[1
,3
,8
,9
]}

Molinuevo, Jose Luis ^{[1
,15
]}

Gispert, Juan Domingo ^{[1
,2
,10
,11
]}

Sala-Vila, Aleix ^{[1
,2
]}

Vilor-Tejedor, Natalia ^{[1
,2
,3
,12
,13
]}

Crous-Bou, Marta ^{[1
,5
,12
,14
]}

机构：

[1] Pasqual Maragall Fdn, Barcelonabeta Brain Res Ctr BBRC, C Wellington 30, Barcelona 08005, Spain

[2] IMIM Hosp del Mar Med Res Inst, C Dr Aiguader 88,2nd Floor,Campus Mar, Barcelona 08003, Spain

[3] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, C Dr Aiguader 88, Barcelona 08003, Spain

[4] Univ Autonoma Barcelona, Barcelona 08193, Spain

[5] Inst Salud Carlos III, Ctr Invest Biomed Red Fragilidad & Envejecimiento, C Monforte Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain

[6] Harvard TH Chan Sch Publ Hlth, Sch Publ Hlth 2, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA

[7] Harvard Med Sch, Channing Div Network Med, Boston, MA 02115 USA

[8] Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Expt & Hlth Sci, Pg Maritim Barceloneta 37, Barcelona 08003, Spain

[9] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain

[10] Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, C Monforte Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain

[11] Ctr Nacl Invest Cardiovasc CNIC, C Melchor Fernandez Almagro 3, Madrid 28029, Spain

[12] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

[13] Univ Pompeu Fabra, C Ramon Trias Fargas 25,27, Barcelona 08005, Spain

[14] Hosp Duran & Reynals, Catalan Inst Oncol ICO, Bellvitge Biomed Res Ctr IDIBELL, Avinguda Granvia Hospitalet 199-203, Barcelona 08908, Spain

[15] H Lundbeck & Co AS, Ottiliavej 9, DK-2500 Copenhagen, Denmark

来源：

NEUROBIOLOGY OF AGING | 2024年 / 141卷

关键词：

Alzheimer's disease; Biological aging; Cognitive performance; Sex differences; Telomere length; MINI-MENTAL STATE; METAANALYSIS; POPULATION; DEMENTIA; VERSION; RECALL; ADULTS;

D O I：

10.1016/j.neurobiolaging.2024.05.015

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.

引用

页码：140 / 150

页数：11

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