Stress responses to bacterial and viral mimetics in polycystic ovary syndrome model rats

被引：0

作者：

Kamada, Shuhei ^{[1
]}

Noguchi, Hiroki ^{[1
]}

Yamamoto, Shota ^{[1
,2
]}

Tamura, Kou ^{[1
]}

Aoki, Hidenori ^{[1
]}

Takeda, Asuka ^{[1
]}

Uchishiba, Maimi ^{[1
]}

Minato, Saki ^{[1
]}

Arata, Moeka ^{[1
]}

Arakaki, Ryosuke ^{[1
]}

Inui, Hiroaki ^{[1
]}

Kagawa, Tomohiro ^{[1
]}

Kawakita, Takako ^{[1
]}

Yoshida, Atsuko ^{[1
]}

Mineda, Ayuka ^{[1
]}

Yamamoto, Yuri ^{[1
]}

Kinouchi, Riyo ^{[1
]}

Yoshida, Kanako ^{[1
]}

Kaji, Takashi ^{[1
]}

Nishimura, Masato ^{[1
]}

Iwasa, Takeshi ^{[1
]}

机构：

[1] Tokushima Univ, Grad Sch Biomed Sci, Dept Obstet & Gynecol, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Renal & Genitourinary Surg, Sapporo, Japan

来源：

BRAIN BEHAVIOR & IMMUNITY-HEALTH | 2024年 / 38卷

关键词：

PCOS; LPS; Poly-IC; Cytokines; Febrile response; Anorectic response; Locomotor activity; TUMOR NECROSIS FACTOR; NERVOUS-SYSTEM; ANXIETY; WOMEN; LIPOPOLYSACCHARIDE; POPULATION; ACTIVATION; DEPRESSION; CHALLENGE; CYTOKINES;

D O I：

10.1016/j.bbih.2024.100772

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polycystic ovary syndrome (PCOS) is associated with an increased risk of psychological distress as well as enhanced responses to psychosocial stress. Recently, it was hypothesized that PCOS patients may be at high risk of novel COVID-19 infections and worse clinical presentations during such infections. Here, we evaluated the effects of PCOS on stress responses to bacterial and viral mimetics using dihydrotestosterone-induced PCOS model rats. Lipopolysaccharide (LPS; a bacterial mimetic) or polyinosinic-polycytidylic acid (Poly-IC; a viral mimetic) was injected into PCOS model rats (PCOS) and non-PCOS rats (control), and the rats' stress responses were evaluated. In the PCOS group, the rats' anorectic and febrile responses to LPS injection were enhanced, whereas their anorectic and febrile responses to Poly-IC injection were unaltered. The PCOS group also exhibited greater changes in peripheral cytokine levels in response to LPS, but not Poly-IC. On the contrary, after the injection of Poly-IC depressed locomotor activity was more evident in the PCOS group, whereas no such changes were observed after LPS injection. These findings indicate that although the stress responses of PCOS model rats to infection may be enhanced, the patterns of change in stress responses and their underlying mechanisms may differ between bacterial and viral infections.

引用

页数：8