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Effects of Portulaca oleracea (purslane) on liver function tests, metabolic profile, oxidative stress and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: a randomized, double-blind clinical trial
被引:2
|作者:
Milkarizi, Narges
[1
,2
]
Barghchi, Hanieh
[1
,2
]
Belyani, Saba
[3
]
Bahari, Hossein
[4
]
Rajabzade, Farnood
[5
]
Ostad, Andisheh Norouzian
[1
]
Goshayeshi, Ladan
[6
,7
]
Nematy, Mohsen
[8
]
Askari, Vahid Reza
[9
,10
]
机构:
[1] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran
[3] North Khorasan Univ Med Sci, Student Res Comm, Bojnurd, Iran
[4] Mashhad Univ Med Sci, Clin Res Inst, Transplant Res Ctr, Mashhad, Iran
[5] Islamic Azad Univ, Dept Radiol, Mashhad Med Sci Branch, Mashhad, Iran
[6] Mashhad Univ Med Sci, Fac Med, Dept Gastroenterol & Hepatol, Mashhad, Iran
[7] Mashhad Univ Med Sci, Gastroenterol & Hepatol Res Ctr, Mashhad, Iran
[8] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran
[9] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran
[10] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran
来源:
FRONTIERS IN NUTRITION
|
2024年
/
11卷
关键词:
non-alcoholic fatty liver;
liver steatosis;
Portulaca oleracea;
oxidative stress;
inflammation;
purslane;
MONOTERPENE GLUCOSIDE;
L;
EXTRACT;
ALKALOIDS;
SUPPLEMENTATION;
FLAVONOIDS;
DAMAGE;
STAGE;
SEEDS;
D O I:
10.3389/fnut.2024.1371137
中图分类号:
R15 [营养卫生、食品卫生];
TS201 [基础科学];
学科分类号:
100403 ;
摘要:
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. Portulaca oleracea exhibits anti-oxidant, anti-inflammatory, and hepatoprotective effects. This clinical trial aimed to investigate the potential benefits of Portulaca oleracea in improving NAFLD. Methods: This double-blind, randomized clinical trial enrolled 70 patients with NAFLD assigned to either the intervention group (n = 35) or placebo group (n = 35) using stratified block randomization. The intervention group received 700 mg Portulaca oleracea supplement for eight weeks, while the control group received placebo capsules. In addition, all participants received a calorie-restricted diet. Liver steatosis and fibrosis were assessed using elastography along with liver function and metabolic tests, blood pressure measurements, body composition analysis and dietary records pre-and post-intervention. Results: The average age of the participants was 44.01 +/- 8.6 years, of which 34 (48.6%) were women. The group receiving Portulaca oleracea showed significant weight changes, body mass index, fat mass index, and waist circumference compared to the placebo (p < 0.001). In addition, blood sugar, lipid profile, liver enzymes aspartate and alanine transaminase, gamma-glutamyl transferase, and systolic blood pressure were significantly improved in the intervention group compared to those in the placebo (p < 0.05). During the study, inflammatory and oxidative stress indicators, improved significantly (p < 0.05). Based on the elastography results, the hepatorenal ultrasound index and liver stiffness decreased significantly in the Portulaca oleracea group compared to the placebo (p < 0.001). Conclusion: The present clinical trial showed that receiving Portulaca oleracea supplement for eight weeks can improve the condition of liver steatosis and fibrosis in patients with NAFLD.
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页数:14
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