Effects of Portulaca oleracea (purslane) on liver function tests, metabolic profile, oxidative stress and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: a randomized, double-blind clinical trial

被引:2
|
作者
Milkarizi, Narges [1 ,2 ]
Barghchi, Hanieh [1 ,2 ]
Belyani, Saba [3 ]
Bahari, Hossein [4 ]
Rajabzade, Farnood [5 ]
Ostad, Andisheh Norouzian [1 ]
Goshayeshi, Ladan [6 ,7 ]
Nematy, Mohsen [8 ]
Askari, Vahid Reza [9 ,10 ]
机构
[1] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran
[3] North Khorasan Univ Med Sci, Student Res Comm, Bojnurd, Iran
[4] Mashhad Univ Med Sci, Clin Res Inst, Transplant Res Ctr, Mashhad, Iran
[5] Islamic Azad Univ, Dept Radiol, Mashhad Med Sci Branch, Mashhad, Iran
[6] Mashhad Univ Med Sci, Fac Med, Dept Gastroenterol & Hepatol, Mashhad, Iran
[7] Mashhad Univ Med Sci, Gastroenterol & Hepatol Res Ctr, Mashhad, Iran
[8] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran
[9] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran
[10] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran
来源
FRONTIERS IN NUTRITION | 2024年 / 11卷
关键词
non-alcoholic fatty liver; liver steatosis; Portulaca oleracea; oxidative stress; inflammation; purslane; MONOTERPENE GLUCOSIDE; L; EXTRACT; ALKALOIDS; SUPPLEMENTATION; FLAVONOIDS; DAMAGE; STAGE; SEEDS;
D O I
10.3389/fnut.2024.1371137
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. Portulaca oleracea exhibits anti-oxidant, anti-inflammatory, and hepatoprotective effects. This clinical trial aimed to investigate the potential benefits of Portulaca oleracea in improving NAFLD. Methods: This double-blind, randomized clinical trial enrolled 70 patients with NAFLD assigned to either the intervention group (n = 35) or placebo group (n = 35) using stratified block randomization. The intervention group received 700 mg Portulaca oleracea supplement for eight weeks, while the control group received placebo capsules. In addition, all participants received a calorie-restricted diet. Liver steatosis and fibrosis were assessed using elastography along with liver function and metabolic tests, blood pressure measurements, body composition analysis and dietary records pre-and post-intervention. Results: The average age of the participants was 44.01 +/- 8.6 years, of which 34 (48.6%) were women. The group receiving Portulaca oleracea showed significant weight changes, body mass index, fat mass index, and waist circumference compared to the placebo (p < 0.001). In addition, blood sugar, lipid profile, liver enzymes aspartate and alanine transaminase, gamma-glutamyl transferase, and systolic blood pressure were significantly improved in the intervention group compared to those in the placebo (p < 0.05). During the study, inflammatory and oxidative stress indicators, improved significantly (p < 0.05). Based on the elastography results, the hepatorenal ultrasound index and liver stiffness decreased significantly in the Portulaca oleracea group compared to the placebo (p < 0.001). Conclusion: The present clinical trial showed that receiving Portulaca oleracea supplement for eight weeks can improve the condition of liver steatosis and fibrosis in patients with NAFLD.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Effect of portulaca oleracea (purslane) extract on inflammatory factors in nonalcoholic fatty liver disease: A randomized, double-blind clinical trial
    Damavandi, Reyhaneh Darvish
    Shidfar, Farzad
    Najafi, Mohammad
    Janani, Leila
    Masoodi, Mohsen
    Heshmati, Javad
    Ziaei, Somayeh
    JOURNAL OF FUNCTIONAL FOODS, 2023, 102
  • [2] Effect of Portulaca Oleracea (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: A randomized, double-blind clinical trial
    Darvish Damavandi, Reyhaneh
    Shidfar, Farzad
    Najafi, Mohammad
    Janani, Leila
    Masoodi, Mohsen
    Akbari-Fakhrabadi, Maryam
    Dehnad, Afsaneh
    PHYTOTHERAPY RESEARCH, 2021, 35 (06) : 3145 - 3156
  • [3] A randomized double-blind clinical trial investigating the effects of ellagic acid on glycemic status, liver enzymes, and oxidative stress in patients with non-alcoholic fatty liver disease
    Mighani, Sara
    Samimi, Rasoul
    Nooshabadi, Mohamadreza Rashidi
    Farzam, Seyed Amir
    Haghighian, Hossein Khadem
    Javadi, Maryam
    BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2025, 25 (01)
  • [4] The effects of zinc supplementation on metabolic profile and oxidative stress in overweight/obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial
    Fathi, Mojdeh
    Alavinejad, Pezhman
    Haidari, Zahra
    Amani, Reza
    JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2020, 62
  • [5] The clinical effects of purslane (Portulaca oleracea) seeds on metabolic profiles in patients with nonalcoholic fatty liver disease: A randomized controlled clinical trial
    Gheflati, Alireza
    Adelnia, Elham
    Nadjarzadeh, Azadeh
    PHYTOTHERAPY RESEARCH, 2019, 33 (05) : 1501 - 1509
  • [6] Nigella sativa and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Results from a randomized, double-blind, placebo-controlled, clinical trial
    Darand, Mina
    Darabi, Zahra
    Yari, Zahra
    Saadati, Saeedeh
    Hedayati, Mehdi
    Khoncheh, Ahmad
    Hosseini-Ahangar, Behnam
    Alavian, Seyed Moayyed
    Hekmatdoost, Azita
    COMPLEMENTARY THERAPIES IN MEDICINE, 2019, 44 : 204 - 209
  • [7] Green Tea in Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial
    Tabatabaee, Seyed Mohammad
    Alavian, Seyed Moayed
    Ghalichi, Leila
    Miryounesi, Seyed Mohammad
    Mousavizadeh, Kazem
    Jazayeri, Shima
    Vafa, Mohammad Reza
    HEPATITIS MONTHLY, 2017, 17 (12)
  • [8] Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial
    Sharifi, Nasrin
    Amani, Reza
    Hajiani, Eskandar
    Cheraghian, Bahman
    ENDOCRINE, 2014, 47 (01) : 70 - 80
  • [9] Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial
    Nasrin Sharifi
    Reza Amani
    Eskandar Hajiani
    Bahman Cheraghian
    Endocrine, 2014, 47 : 70 - 80
  • [10] The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial
    Bahrami, Mina
    Cheraghpour, Makan
    Jafarirad, Sima
    Alavinejad, Pejman
    Asadi, Fariba
    Hekmatdoost, Azita
    Mohammadi, Mahsa
    Yari, Zahra
    COMPLEMENTARY THERAPIES IN MEDICINE, 2020, 52