Current development of molecular classifications of gastric cancer based on omics (Review)

被引:3
作者
Ma, Yubo [1 ]
Jiang, Zhengchen [2 ,3 ]
Pan, Libin [4 ]
Zhou, Ying [4 ]
Xia, Ruihong [1 ]
Liu, Zhuo [2 ]
Yuan, Li [3 ,5 ,6 ]
机构
[1] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Dept Gastr Surg, Banshan Rd 1, Hangzhou 310022, Zhejiang, Peoples R China
[3] Zhejiang Canc Hosp, Zhejiang Key Lab Prevent Diag & Therapy Upper Gast, Banshan Rd 1, Hangzhou 310022, Zhejiang, Peoples R China
[4] Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Dept Pharm, Hangzhou 310005, Zhejiang, Peoples R China
[5] Zhejiang Canc Hosp, Zhejiang Prov Res Ctr Upper Gastrointestinal Tract, Hangzhou 310022, Zhejiang, Peoples R China
[6] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Dept Integrated Chinese & Western Med, Hangzhou 310022, Zhejiang, Peoples R China
基金
国家重点研发计划;
关键词
gastric cancer; cluster classification; heterogeneity; therapy; HOMOLOGOUS RECOMBINATION DEFICIENCY; MISMATCH REPAIR DEFICIENCY; GASTROESOPHAGEAL JUNCTION; ESOPHAGOGASTRIC JUNCTION; THYMIDYLATE SYNTHASE; PROGNOSTIC VALUE; EXPRESSION; SUBTYPES; DNA; ADENOCARCINOMA;
D O I
10.3892/ijo.2024.5677
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Gastric cancer (GC) is a complex and heterogeneous disease with significant phenotypic and genetic variation. Traditional classification systems rely mainly on the evaluation of clinical pathological features and conventional biomarkers and might not capture the diverse clinical processes of individual GCs. The latest discoveries in omics technologies such as next-generation sequencing, proteomics and metabolomics have provided crucial insights into potential genetic alterations and biological events in GC. Clustering strategies for identifying subtypes of GC might offer new tools for improving GC treatment and clinical trial outcomes by enabling the development of therapies tailored to specific subtypes. However, the feasibility and therapeutic significance of implementing molecular classifications of GC in clinical practice need to addressed. The present review examines the current molecular classifications, delineates the prevailing landscape of clinically relevant molecular features, analyzes their correlations with traditional GC classifications, and discusses potential clinical applications.
引用
收藏
页数:22
相关论文
共 163 条
[1]   Current developments in gastric cancer: from molecular profiling to treatment strategy [J].
Alsina, Maria ;
Arrazubi, Virginia ;
Diez, Marc ;
Tabernero, Josep .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2023, 20 (03) :155-170
[2]   CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients [J].
Bae, Jun Sang ;
Park, See-Hyoung ;
Jamiyandorj, Urangoo ;
Kim, Kyoung Min ;
Noh, Sang Jae ;
Kim, Jung Ryul ;
Park, Hye Jeong ;
Kwon, Keun Sang ;
Jung, Sung Hoo ;
Park, Ho Sung ;
Park, Byung-Hyun ;
Lee, Ho ;
Moon, Woo Sung ;
Sylvester, Karl G. ;
Jang, Kyu Yun .
AMERICAN JOURNAL OF PATHOLOGY, 2016, 186 (12) :3297-3315
[3]   Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer [J].
Bai, Yuezong ;
Xie, Tong ;
Wang, Zhenghang ;
Tong, Shuang ;
Zhao, Xiaochen ;
Zhao, Feilong ;
Cai, Jinping ;
Wei, Xiaofan ;
Peng, Zhi ;
Shen, Lin .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (03)
[4]   Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial [J].
Bang, Yung-Jue ;
Kim, Young-Woo ;
Yang, Han-Kwang ;
Chung, Hyun Cheol ;
Park, Young-Kyu ;
Lee, Kyung Hee ;
Lee, Keun-Wook ;
Kim, Yong Ho ;
Noh, Sang-Ik ;
Cho, Jae Yong ;
Mok, Young Jae ;
Kim, Yeul Hong ;
Ji, Jiafu ;
Yeh, Ta-Sen ;
Button, Peter ;
Sirzen, Florin ;
Noh, Sung Hoon .
LANCET, 2012, 379 (9813) :315-321
[5]   HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer [J].
Barnes, Tristan A. ;
Amir, Eitan .
BRITISH JOURNAL OF CANCER, 2017, 117 (04) :451-460
[6]   Comprehensive molecular characterization of gastric adenocarcinoma [J].
Bass, Adam J. ;
Thorsson, Vesteinn ;
Shmulevich, Ilya ;
Reynolds, Sheila M. ;
Miller, Michael ;
Bernard, Brady ;
Hinoue, Toshinori ;
Laird, Peter W. ;
Curtis, Christina ;
Shen, Hui ;
Weisenberger, Daniel J. ;
Schultz, Nikolaus ;
Shen, Ronglai ;
Weinhold, Nils ;
Keiser, David P. ;
Bowlby, Reanne ;
Sipahimalani, Payal ;
Cherniack, Andrew D. ;
Getz, Gad ;
Liu, Yingchun ;
Noble, Michael S. ;
Pedamallu, Chandra ;
Sougnez, Carrie ;
Taylor-Weiner, Amaro ;
Akbani, Rehan ;
Lee, Ju-Seog ;
Liu, Wenbin ;
Mills, Gordon B. ;
Yang, Da ;
Zhang, Wei ;
Pantazi, Angeliki ;
Parfenov, Michael ;
Gulley, Margaret ;
Piazuelo, M. Blanca ;
Schneider, Barbara G. ;
Kim, Jihun ;
Boussioutas, Alex ;
Sheth, Margi ;
Demchok, John A. ;
Rabkin, Charles S. ;
Willis, Joseph E. ;
Ng, Sam ;
Garman, Katherine ;
Beer, David G. ;
Pennathur, Arjun ;
Raphael, Benjamin J. ;
Wu, Hsin-Ta ;
Odze, Robert ;
Kim, Hark K. ;
Bowen, Jay .
NATURE, 2014, 513 (7517) :202-209
[7]   Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction [J].
Bornschein, Jan ;
Wernisch, Lorenz ;
Secrier, Maria ;
Miremadi, Ahmad ;
Perner, Juliane ;
MacRae, Shona ;
O'Donovan, Maria ;
Newton, Richard ;
Menon, Suraj ;
Bower, Lawrence ;
Eldridge, Matthew D. ;
Devonshire, Ginny ;
Cheah, Calvin ;
Turkington, Richard ;
Hardwick, Richard H. ;
Selgrad, Michael ;
Venerito, Marino ;
Malfertheiner, Peter ;
Fitzgerald, Rebecca C. ;
Noorani, Ayesha ;
Elliott, Rachael Fels ;
Edwards, Paul A. W. ;
Grehan, Nicola ;
Nutzinger, Barbara ;
Crawte, Jason ;
Chettouh, Hamza ;
Contino, Gianmarco ;
Li, Xiaodun ;
Gregson, Eleanor ;
Zeki, Sebastian ;
de la Rue, Rachel ;
Malhotra, Shalini ;
Tavare, Simon ;
Lynch, Andy G. ;
Smith, Mike L. ;
Davies, Jim ;
Crichton, Charles ;
Carroll, Nick ;
Safranek, Peter ;
Hindmarsh, Andrew ;
Sujendran, Vijayendran ;
Hayes, Stephen J. ;
Ang, Yeng ;
Preston, Shaun R. ;
Oakes, Sarah ;
Bagwan, Izhar ;
Save, Vicki ;
Skipworth, Richard J. E. ;
Hupp, Ted R. ;
O'Neill, J. Robert .
INTERNATIONAL JOURNAL OF CANCER, 2019, 145 (12) :3389-3401
[8]   SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer [J].
Botta, Gregory P. ;
Kato, Shumei ;
Patel, Hitendra ;
Fanta, Paul ;
Lee, Suzanna ;
Okamura, Ryosuke ;
Kurzrock, Razelle .
JCI INSIGHT, 2021, 6 (18)
[9]   EMT in cancer [J].
Brabletz, Thomas ;
Kalluri, Raghu ;
Angela Nieto, M. ;
Weinberg, Robert A. .
NATURE REVIEWS CANCER, 2018, 18 (02) :128-+
[10]   EMT and MET in Metastasis: Where Are the Cancer Stem Cells? [J].
Brabletz, Thomas .
CANCER CELL, 2012, 22 (06) :699-701