STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy

被引：0
作者：
Pessolano, Emanuela [1 ]
Sosic, Zlata A. [2 ]
Genazzani, Armando A. [2 ]
机构：
[1] Univ Piemonte Orientale, Dept Pharmaceut Sci, Novara, Italy
[2] Univ Turin, Dept Drug Sci & Technol, Turin, Italy
来源：
CELL CALCIUM | 2024年 / 123卷
关键词：
Store-operated calcium-entry; STIM1; Nuclear calcium; Tubular aggregate myopathy; ORAI1; DNA repair; PLATELET ACTIVATION;
D O I：
10.1016/j.ceca.2024.102926
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Two recent papers have highlighted that STIM1, a key component of Store-operated Ca2 +-entry, is able to translocate to the nucleus and participate in nuclear Ca2 +-handling and in DNA repair. These finding opens new avenues on the role that this Ca 2 +-sensing protein may have in health and disease.
引用
收藏
页数：3
相关论文
共 10 条
  • [1] The D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice
    Bryson, Victoria
    Wang, Chaojian
    Zhou, Zirui
    Singh, Kavisha
    Volin, Noah
    Yildirim, Eda
    Rosenberg, Paul
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2024, 134 (07)
  • [2] CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy
    Cordero-Sanchez, Celia
    Pessolano, Emanuela
    Riva, Beatrice
    Vismara, Mauro
    Trivigno, Silvia Maria Grazia
    Clemente, Nausicaa
    Aprile, Silvio
    Ruffinatti, Federico Alessandro
    Portararo, Paola
    Filigheddu, Nicoletta
    Zaggia, Ivan
    Bhela, Irene P.
    Serafini, Marta
    Pirali, Tracey
    Colombo, Mario P.
    Torti, Mauro
    Sangaletti, Sabina
    Bertoni, Alessandra
    Genazzani, Armando A.
    [J]. BLOOD ADVANCES, 2022, 6 (15) : 4471 - 4484
  • [3] STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
    Gamage, Thilini H.
    Gunnes, Gjermund
    Lee, Robert Hugh
    Louch, William Edward
    Holmgren, Asbjorn
    Bruton, Joseph D.
    Lengle, Emma
    Kolstad, Terje R. Selnes
    Revold, Tobias
    Amundsen, Silja Svanstrom
    Dalen, Knut Tomas
    Holme, Pal Andre
    Tjonnfjord, Geir Erland
    Christensen, Geir
    Westerblad, Hakan
    Klungland, Arne
    Bergmeier, Wolfgang
    Misceo, Doriana
    Frengen, Eirik
    [J]. CELL CALCIUM, 2018, 76 : 87 - 100
  • [4] An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice
    Grosse, Johannes
    Braun, Attila
    Varga-Szabo, David
    Beyersdorf, Niklas
    Schneider, Boris
    Zeitlmann, Lutz
    Hanke, Petra
    Schropp, Patricia
    Muehlstedt, Silke
    Zorn, Carolin
    Huber, Michael
    Schmittwolf, Carolin
    Jagla, Wolfgang
    Yu, Philipp
    Kerkau, Thomas
    Schulze, Harald
    Nehls, Michael
    Nieswandt, Bernhard
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (11) : 3540 - 3550
  • [5] Tubular aggregate myopathy and Stormorken syndrome: Mutation spectrum and genotype/phenotype correlation
    Morin, Gilles
    Biancalana, Valerie
    Echaniz-Laguna, Andoni
    Noury, Jean-Baptiste
    Lornage, Xayiere
    Moggio, Maurizio
    Ripolone, Michela
    Violano, Raffaella
    Marcorelles, Pascale
    Marechal, Denis
    Renaud, Florence
    Maurage, Claude-Alain
    Tard, Celine
    Cuisset, Jean-Marie
    Laporte, Jocelyn
    Bohm, Johann
    [J]. HUMAN MUTATION, 2020, 41 (01) : 17 - 37
  • [6] STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39
    Riva, Beatrice
    Pessolano, Emanuela
    Quaglia, Edoardo
    Cordero-Sanchez, Celia
    Bhela, Irene P.
    Topf, Ana
    Serafini, Marta
    Cox, Daniel
    Harris, Elizabeth
    Garibaldi, Matteo
    Barresi, Rita
    Pirali, Tracey
    Genazzani, Armando A.
    [J]. CELL CALCIUM, 2022, 105
  • [7] STIM1 translocation to the nucleus protects cells from DNA damage
    Sanchez-Lopez, Irene
    Orantos-Aguilera, Yolanda
    Pozo-Guisado, Eulalia
    Alvarez-Barientos, Alberto
    Lilla, Sergio
    Zanivan, Sara
    Lachaud, Christophe
    Martin-Romero, Francisco Javier
    [J]. NUCLEIC ACIDS RESEARCH, 2024, 52 (05) : 2389 - 2415
  • [8] Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice
    Silva-Rojas, Roberto
    Perez-Guardia, Laura
    Lafabrie, Emma
    Moulaert, David
    Laporte, Jocelyn
    Bohm, Johann
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)
  • [9] The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
    Srikanth, Sonal
    Woo, Jin Seok
    Wu, Beibei
    El-Sherbiny, Yasser M.
    Leung, Jennifer
    Chupradit, Koollawat
    Rice, Laura
    Seo, Gil Ju
    Calmettes, Guillaume
    Ramakrishna, Chandran
    Cantin, Edouard
    An, Dong Sung
    Sun, Ren
    Wu, Ting-Ting
    Jung, Jae U.
    Savic, Sinisa
    Gwack, Yousang
    [J]. NATURE IMMUNOLOGY, 2019, 20 (02) : 152 - +
  • [10] CASQ1-related myopathy: The first report from China and the literature review
    Zhang, Kai-Yue
    Zhang, Geng-Jian
    Duan, Hui-Qian
    Li, Qiu-Xiang
    Huang, Kun
    Xu, Li-Qun
    Yang, Huan
    Luo, Yue-Bei
    [J]. CLINICAL CASE REPORTS, 2022, 10 (12):
1