Synthesis and biological evaluation of amide derivatives of benzoxazole linked Imidazo[2,1-b][1,3,4]thiadiazole as antiproliferative agents

被引：2

作者：

Bhogireddy, Danayya Nayudu ^{[1
,2
]}

Surapureddi, Sri Ramakrishna ^{[1
]}

Palle, Sadanandam ^{[3
]}

Tadiboina, Bhaskara Rao ^{[1
]}

机构：

[1] Koneru Lakshmaiah Educ Fdn, Dept Chem, Green Fields, Guntur 522502, India

[2] Genome Valley, Laurus Labs Ltd, Telangana, IKP Knowledge Pk, Hyderabad 500078, India

[3] JNTUH, Inst Sci & Technol, Ctr Chem Sci & Technol, Hyderbad, Telangana, India

来源：

CHEMICAL DATA COLLECTIONS | 2022年 / 39卷

关键词：

5-Formyl-6-phenylimidazo-[2; 1-b][1; 4; thiadiazole sulfonamide; Benoxaprofen; Benzoxazole and anticancer; DIURETIC ACTIVITY; BENZIMIDAZOLE;

D O I：

10.1016/j.cdc.2022.100856

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of various substituted aryl and hetero aryl amide derivatives of benzoxazole linked imidazo[2,1-b][1,3,4]thiadiazole (11a-j) were synthesized and their structures confirmed by spectral data. These newly synthesized compounds (11a-j) were evaluated for their anticancer profile towards human prostate cancer (PC3 and DU-145), lung cancer (A549) and breast cancer (MCF-7) cell lines by used of MTT assay and etoposide was chosen as positive control. Most of the derivatives displayed good to moderate antiproliferative activities with respective cell lines. Among the evaluated compounds, four compounds (11a, 11b, 11c and 11d) demonstrated more potent anticancer activity. Particularly, compound 11a showed strongest activity as etoposide.

引用

页数：9

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