Causal Relationships between Polyunsaturated Fatty Acids and Colon Polyps: A Two-Sample Mendelian Randomization Study

被引:0
|
作者
Shen, Na [1 ]
Ba, Qinwen [1 ]
Lu, Yanjun [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan 430030, Peoples R China
关键词
colon polyps; mendelian randomization; fatty acids; causality; COLORECTAL-CANCER; DOCOSAHEXAENOIC ACID; OXIDATIVE STRESS; RISK; N-3; ADENOMA; OMEGA-3-FATTY-ACIDS; CELLS;
D O I
10.3390/nu16132033
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Epidemiological studies have shown that fatty acids, especially polyunsaturated fatty acids (PUFAs), influence colorectal carcinogenesis. Colon polyps, particularly those identified as precancerous, are a frequently encountered phenomenon associated with PUFAs. However, the results are inconsistent. Therefore, we investigated the effect of PUFAs on colon polyps in individuals of European ancestry. Methods: Single nucleotide polymorphisms correlating with PUFAs and colon polyps were derived from extensive genome-wide association studies, encompassing a discovery cohort of 135,006 samples and a corresponding validation set with 114,999 samples. Causality was assessed by employing a range of techniques, such as inverse variance weighted (IVW), weighted median, MR-Egger, and simple and weighted modes. The analysis was complemented with sensitivity checks using leave-one-out and heterogeneity evaluation through MR-IVW and Cochran's Q. Results: A thorough analysis was performed to examine the causal effects of PUFAs on the development of colon polyps. The findings indicated that levels of Omega-3 fatty acids (OR = 1.0014, 95% CI 1.0004-1.0024, p = 0.004), the ratio of Docosahexaenoic acid (DHA)/total fatty acids (FAs) (DHA/totalFA; OR = 1.0015, 95% CI 1.0002-1.0028, p = 0.023), and the ratio of Omega-3/totalFA (Omega-3/totalFA; OR = 1.0013, 95% CI 1.0003-1.0022, p = 0.010) were identified as biomarkers associated with an increased risk of colon polyps. Conversely, the ratio of Omega-6/Omega-3 (OR = 0.9986, 95% CI 0.9976-0.9995, p = 0.003) and the ratio of Linoleic acid (LA)/totalFA (LA/totalFA; OR = 0.9981, 95% CI 0.9962-0.9999, p = 0.044) were negatively associated with susceptibility to colon polyps. The MR-Egger and MR-IVW analysis revealed that pleiotropy and heterogeneity did not significantly impact the outcomes. Conclusion: This study has uncovered a possible adverse effect of PUFAs, notably Omega-3, on the formation of colon polyps. Elevated Omega-3 levels were correlated with a heightened risk of colon polyps.
引用
收藏
页数:12
相关论文
共 50 条
  • [41] Causal relationships between peripheral immune cells and Alzheimer's disease: a two-sample Mendelian randomization study
    Liao, Jing
    Zhang, Yongquan
    Tang, Zhanhong
    Liu, Pinjing
    He, Luoyi
    NEUROLOGICAL SCIENCES, 2024, 45 (07) : 3117 - 3124
  • [42] Causal relationships between immune cell phenotypes and lung adenocarcinoma: A bidirectional two-sample Mendelian randomization study
    Li, Bowen
    Huang, Zhicheng
    Wang, Yadong
    Guo, Chao
    Liang, Naixin
    Yang, Huaxia
    Li, Shanqing
    THORACIC CANCER, 2024, 15 (21) : 1673 - 1680
  • [43] Causal relationship between human blood omega-3 fatty acids and the risk of epilepsy: A two-sample Mendelian randomization study
    Liang, Zhen
    Lou, Yingyue
    Li, Zijian
    Liu, Songyan
    FRONTIERS IN NEUROLOGY, 2023, 14
  • [44] Causal relationships between potential risk factors and chronic rhinosinusitis: a bidirectional two-sample Mendelian randomization study
    Zhang, Zengxiao
    Li, Gongfei
    Yu, Longgang
    Jiang, Jiaxin
    Li, Ruixia
    Zhou, Shizhe
    Jiang, Yan
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2023, 280 (06) : 2785 - 2793
  • [45] Causal relationships between dietary antioxidant vitamin intake and atopic dermatitis: A two-sample Mendelian randomization study
    Wang, Siqing
    Dan, Wenchao
    Wang, Zixuan
    Sun, Yujie
    Zhang, Guangzhong
    SKIN RESEARCH AND TECHNOLOGY, 2024, 30 (08)
  • [46] Causal relationships between potential risk factors and chronic rhinosinusitis: a bidirectional two-sample Mendelian randomization study
    Zengxiao Zhang
    Gongfei Li
    Longgang Yu
    Jiaxin Jiang
    Ruixia Li
    Shizhe Zhou
    Yan Jiang
    European Archives of Oto-Rhino-Laryngology, 2023, 280 : 2785 - 2793
  • [47] Causal relationships between psychological disorders and functional gastrointestinal disorders: a bidirectional two-sample Mendelian randomization study
    Liu, Tangyi
    Wang, Zeyu
    Kang, Xiaoyu
    Wang, Xiangping
    Ren, Gui
    Lv, Yong
    Li, Jing
    Liu, Yaling
    Liang, Shuhui
    Nie, Yongzhan
    Luo, Hui
    Pan, Yanglin
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2024, 36 (11) : 1267 - 1274
  • [48] Causal relationships between rheumatoid arthritis and neurodegenerative diseases: a two-sample univariable and multivariable Mendelian randomization study
    Chen, Xingyu
    Cai, Li
    Fan, Weibing
    Yang, Qian
    Mao, Xinfa
    Yao, Liping
    FRONTIERS IN MEDICINE, 2024, 11
  • [49] The Effects of Fatty Acids on Inflammatory Bowel Disease: A Two-Sample Mendelian Randomization Study
    He, Jian
    Luo, Xiaobei
    Xin, Hongjie
    Lai, Qianwei
    Zhou, Yuanping
    Bai, Yang
    NUTRIENTS, 2022, 14 (14)
  • [50] Causal Relationships between Lymphocyte Subsets and Risk of Coronary Artery Disease: A Two-Sample Mendelian Randomization Study
    Ma, Zhao
    Liu, Libo
    Tian, Jinfan
    Tu, Chenchen
    Zhang, Dongfeng
    Zhang, Mingduo
    Zhang, Huan
    An, Ziyu
    Sun, Meichen
    Zhang, Hongjia
    Song, Xiantao
    REVIEWS IN CARDIOVASCULAR MEDICINE, 2024, 25 (09)