Salivary Metabolites Produced by Oral Microbes in Oral Diseases and Oral Squamous Cell Carcinoma: A Review

被引：10

作者：

Kashyap, Bina ^{[1
]}

Kullaa, Arja ^{[1
]}

机构：

[1] Univ Eastern Finland, Inst Dent, Kuopio 70211, Finland

来源：

METABOLITES | 2024年 / 14卷 / 05期

关键词：

dysbiosis; oral microbiome; saliva; metabolites; oral disease; oral cancer; FUSOBACTERIUM-NUCLEATUM; PORPHYROMONAS-GINGIVALIS; STREPTOCOCCUS-CRISTATUS; METHYL MERCAPTAN; BIOMARKERS; CANCER; IDENTIFICATION; BACTERIA; CARCINOGENESIS; INFLAMMATION;

D O I：

10.3390/metabo14050277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, salivary metabolome studies have provided new biological information and salivary biomarkers to diagnose different diseases at early stages. The saliva in the oral cavity is influenced by many factors that are reflected in the salivary metabolite profile. Oral microbes can alter the salivary metabolite profile and may express oral inflammation or oral diseases. The released microbial metabolites in the saliva represent the altered biochemical pathways in the oral cavity. This review highlights the oral microbial profile and microbial metabolites released in saliva and its use as a diagnostic biofluid for different oral diseases. The importance of salivary metabolites produced by oral microbes as risk factors for oral diseases and their possible relationship in oral carcinogenesis is discussed.

引用

页数：21

共 163 条

[1] Defining the normal bacterial flora of the oral cavity [J].

Aas, JA ;

Paster, BJ ;

Stokes, LN ;

Olsen, I ;

Dewhirst, FE .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (11) :5721-5732

[2] Bacterial Quorum Sensing and Microbial Community Interactions [J].

Abisado, Rhea G. ;

Benomar, Saida ;

Klaus, Jennifer R. ;

Dandekar, Ajai A. ;

Chandler, Josephine R. .

MBIO, 2018, 9 (03)

[3] Inflammatory bacteriome featuring Fusobacterium nucleatum and Pseudomonas aeruginosa identified in association with oral squamous cell carcinoma [J].

Al-hebshi, Nezar Noor ;

Nasher, Akram Thabet ;

Maryoud, Mohamed Yousef ;

Homeida, Husham E. ;

Chen, Tsute ;

Idris, Ali Mohamed ;

Johnson, Newell W. .

SCIENTIFIC REPORTS, 2017, 7

[4] Acetaldehyde production byRothia mucilaginosaisolates from patients with oral leukoplakia [J].

Amer, Abdrazak ;

Whelan, Aine ;

Al-Hebshi, Nezar N. ;

Healy, Claire M. ;

Moran, Gary P. .

JOURNAL OF ORAL MICROBIOLOGY, 2020, 12 (01)

[5] The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for Fusobacterium, Leptotrichia, Campylobacter, and Rothia Species [J].

Amer, Abdrazak ;

Galvin, Sheila ;

Healy, Claire M. ;

Moran, Gary P. .

FRONTIERS IN MICROBIOLOGY, 2017, 8

[6] Polyamine biomarkers as indicators of human disease [J].

Amin, Mohsin ;

Tang, Shiying ;

Shalamanova, Liliana ;

Taylor, Rebecca L. ;

Wylie, Stephen ;

Abdullah, Badr M. ;

Whitehead, Kathryn A. .

BIOMARKERS, 2021, 26 (02) :77-94

[7]

Aruni A Wilson, 2015, Curr Oral Health Rep, V2, P48

[8] Role of bacterial volatile compounds in bacterial biology [J].

Audrain, Bianca ;

Farag, Mohamed A. ;

Ryu, Choong-Min ;

Ghigo, Jean-Marc .

FEMS MICROBIOLOGY REVIEWS, 2015, 39 (02) :222-233

[9] Oral Microbiome: Getting to Know and Befriend Neighbors, a Biological Approach [J].

Bacali, Cecilia ;

Vulturar, Romana ;

Buduru, Smaranda ;

Cozma, Angela ;

Fodor, Adriana ;

Chis, Adina ;

Lucaciu, Ondine ;

Damian, Laura ;

Moldovan, Mirela Liliana .

BIOMEDICINES, 2022, 10 (03)

[10] Global Metabolomic Analysis of Human Saliva and Plasma from Healthy and Diabetic Subjects, with and without Periodontal Disease [J].

Barnes, Virginia M. ;

Kennedy, Adam D. ;

Panagakos, Fotinos ;

Devizio, William ;

Trivedi, Harsh M. ;

Joensson, Thomas ;

Guo, Lining ;

Cervi, Shannon ;

Scannapieco, Frank A. .

PLOS ONE, 2014, 9 (08)

← 1 2 3 4 5 6 7 8 9 10 →