Fusarium, Scedosporium and Other Rare Mold Invasive Infections: Over Twenty-Five-Year Experience of a European Tertiary-Care Center

被引:1
作者
Ledoux, Marie-Pierre [1 ]
Dicop, Elise [2 ]
Sabou, Marcela [3 ,4 ]
Letscher-Bru, Valerie [3 ,4 ]
Castelain, Vincent [5 ]
Danion, Francois [6 ,7 ]
Herbrecht, Raoul [1 ]
机构
[1] Inst Cancerol Strasbourg, Dept Hematol, F-67033 Strasbourg, France
[2] Elsan, Clin Oncol, F-67000 Strasbourg, France
[3] Hop Univ Strasbourg, Plateau Tech Microbiol, Lab Parasitol & Mycol Med, F-67000 Strasbourg, France
[4] Univ Strasbourg, Inst Parasitol & Pathol Trop, Pathogens Host Arthropods Vectors Interact, UR 3073, F-67000 Strasbourg, France
[5] Hop Univ Strasbourg, Intens Care Unit, F-67000 Strasbourg, France
[6] Hop Univ Strasbourg, Dept Infect Dis, F-67000 Strasbourg, France
[7] INSERM UMR S1109, F-67200 Strasbourg, France
关键词
invasive mold disease; fungal infection; Fusarium; Scedosporium; Alternaria; Phaeohyphomycetes; Hyalohyphomycetes; immunocompromised patients; CELL TRANSPLANT RECIPIENTS; FUNGAL-INFECTIONS; DIAGNOSIS; SPP; PHEOHYPHOMYCOSIS; EPIDEMIOLOGY; SURVEILLANCE; ASPERGILLOSIS; GUIDELINES; MANAGEMENT;
D O I
10.3390/jof10040289
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Invasive mold infections (IMD) are an emerging concern due to the growing prevalence of patients at risk, encompassing but not limited to allogeneic hematopoietic stem cell transplant recipients, hematological malignancies patients, solid organ transplant recipients and intensive care unit patients. In contrast with invasive aspergillosis and mucormycosis, other hyalohyphomycoses and phaeohyphomycoses remain poorly known. We conducted a retrospective analysis of the clinical, biological, microbiological and evolutive features of 92 IMD having occurred in patients in our tertiary-care center over more than 25 years. A quarter of these infections were due to multiple molds. Molds involved were Fusarium spp. (36.2% of IMD with a single agent, 43.5% of IMD with multiple agents), followed by Scedosporium spp. (respectively 14.5% and 26.1%) and Alternaria spp. (respectively 13.0% and 8.7%). Mortality at day 84 was higher for Fusarium spp., Scedosporium spp. or multiple pathogens IMD compared with Alternaria or other pathogens (51.7% vs. 17.6%, p < 0.05). Mortality at day 84 was also influenced by host factor: higher among hematology and alloHSCT patients than in other patients (30.6% vs. 20.9% at day 42 and 50.0% vs. 27.9% at day 84, p = 0.041). Better awareness, understanding and treatments are awaited to improve patient prognosis.
引用
收藏
页数:16
相关论文
共 50 条
[1]   Invasive pulmonary infection due to Trichoderma longibrachiatum mimicking invasive aspergillosis in a neutropenic patient successfully treated with voriconazole combined with caspofungin [J].
Alanio, Alexandre ;
Brethon, Benoit ;
de Chauvin, Martine Feuilhade ;
de Kerviler, Eric ;
Leblanc, Thierry ;
Lacroix, Claire ;
Baruchel, Andre ;
Menotti, Jean .
CLINICAL INFECTIOUS DISEASES, 2008, 46 (10) :E116-E118
[2]   Alternaria infectoria skin infection in a renal transplant recipient: an emerging phaeohyphomycosis of occidental countries? [J].
Aragon-Miguel, Raquel ;
Calleja-Algarra, Alba ;
Morales-Raya, Carlos ;
Ortiz-Romero, Pablo L. ;
Maronas-Jimenez, Lidia ;
Lopez-Medrano, Francisco ;
Perez-Ayala, Ana ;
Rodriguez-Peralto, Jose L. .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2017, 56 (07) :E153-E155
[3]   Scedosporiosis/lomentosporiosis observational study (SOS): Clinical significance of Scedosporium species identification [J].
Bronnimann, Didier ;
Garcia-Hermoso, Dea ;
Dromer, Francoise ;
Lanternier, Fanny .
MEDICAL MYCOLOGY, 2021, 59 (05) :486-497
[4]   Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways [J].
Chamilos, Georgios ;
Lionakis, Michail S. ;
Kontoyiannis, Dimitrios P. .
CLINICAL INFECTIOUS DISEASES, 2018, 66 (01) :140-148
[5]   Scedosporium and Lomentospora Infections: Contemporary Microbiological Tools for the Diagnosis of Invasive Disease [J].
Chen, Sharon C. -A. ;
Halliday, Catriona L. ;
Hoenigl, Martin ;
Cornely, Oliver A. ;
Meyer, Wieland .
JOURNAL OF FUNGI, 2021, 7 (01) :1-18
[6]   ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi [J].
Chowdhary, A. ;
Meis, J. F. ;
Guarro, J. ;
de Hoog, G. S. ;
Kathuria, S. ;
Arendrup, M. C. ;
Arikan-Akdagli, S. ;
Akova, M. ;
Boekhout, T. ;
Caira, M. ;
Guinea, J. ;
Chakrabarti, A. ;
Dannaoui, E. ;
van Diepeningen, A. ;
Freiberger, T. ;
Groll, A. H. ;
Hope, W. W. ;
Johnson, E. ;
Lackner, M. ;
Lagrou, K. ;
Lanternier, F. ;
Lass-Floerl, C. ;
Lortholary, O. ;
Meletiadis, J. ;
Munoz, P. ;
Pagano, L. ;
Petrikkos, G. ;
Richardson, M. D. ;
Roilides, E. ;
Skiada, A. ;
Tortorano, A. M. ;
Ullmann, A. J. ;
Verweij, P. E. ;
Cornely, O. A. ;
Cuenca-Estrella, M. .
CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 :47-75
[7]   Dual Invasive Infection with Phaeoacremonium parasiticum and Paraconiothyrium cyclothyrioides in a Renal Transplant Recipient: Case Report and Comprehensive Review of the Literature of Phaeoacremonium Phaeohyphomycosis [J].
Colombier, Marie-Alice ;
Alanio, Alexandre ;
Denis, Blandine ;
Melica, Giovanna ;
Garcia-Hermoso, Dea ;
Levy, Benedicte ;
Peraldi, Marie-Noelle ;
Glotz, Denis ;
Bretagne, Stephane ;
Gallien, Sebastien .
JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (07) :2084-2094
[8]   Factors associated with coinfections in invasive aspergillosis: a retrospective cohort study [J].
Danion, Francois ;
Duval, Celine ;
Severac, Francois ;
Bachellier, Philippe ;
Candol, Ermanno ;
Castelain, Vincent ;
Clere-Jehl, Raphael ;
Denis, Julie ;
Dillenseger, Laurence ;
Epailly, Eric ;
Gantzer, Justine ;
Guffroy, Blandine ;
Hansmann, Yves ;
Herbrecht, Jean-Etienne ;
Letscher-Bru, Valerie ;
Leyendecker, Pierre ;
Ouven, Pauline Le Van ;
Ludes, Pierre-Olivier ;
Morel, Guillaume ;
Moulin, Bruno ;
Paillard, Catherine ;
Renaud-Picard, Benjamin ;
Roche, Anne-Claude ;
Sabou, Marcela ;
Schneider, Francis ;
Solis, Morgane ;
Talagrand-Reboul, Emilie ;
Veillon, Francis ;
Ledoux, Marie-Pierre ;
Simand, Celestine ;
Herbrecht, Raoul .
CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (11) :1644-1651
[9]   Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium [J].
Donnelly, J. Peter ;
Chen, Sharon C. ;
Kauffman, Carol A. ;
Steinbach, William J. ;
Baddley, John W. ;
Verweij, Paul E. ;
Clancy, Cornelius J. ;
Wingard, John R. ;
Lockhart, Shawn R. ;
Groll, Andreas H. ;
Sorrell, Tania C. ;
Bassetti, Matteo ;
Akan, Hamdi ;
Alexander, Barbara D. ;
Andes, David ;
Azoulay, Elie ;
Bialek, Ralf ;
Bradsher, Robert W., Jr. ;
Bretagne, Stephane ;
Calandra, Thierry ;
Caliendo, Angela M. ;
Castagnola, Elio ;
Cruciani, Mario ;
Cuenca-Estrella, Manuel ;
Decker, Catherine F. ;
Desai, Sujal R. ;
Fisher, Brian ;
Harrison, Thomas ;
Heussel, Claus Peter ;
Jensen, Henrik E. ;
Kibbler, Christopher C. ;
Kontoyiannis, Dimitrios P. ;
Kullberg, Bart-Jan ;
Lagrou, Katrien ;
Lamoth, Frederic ;
Lehrnbecher, Thomas ;
Loeffler, Jurgen ;
Lortholary, Olivier ;
Maertens, Johan ;
Marchetti, Oscar ;
Marr, Kieren A. ;
Masur, Henry ;
Meis, Jacques F. ;
Morrisey, C. Orla ;
Nucci, Marcio ;
Ostrosky-Zeichner, Luis ;
Pagano, Livio ;
Patterson, Thomas F. ;
Perfect, John R. ;
Racil, Zdenek .
CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) :1367-1376
[10]  
Garnacho-Montero J, 2013, REV ESP QUIM, V26, P173