CD147 regulates the formation and function of immune synapses

被引:0
|
作者
Xu, Yingming [1 ]
Zhang, Kui [1 ]
Miao, Jinlin [1 ]
Guo, Na [1 ,2 ]
Fu, Xianghui [1 ]
Yang, Fengfan [1 ]
Luo, Xing [1 ]
Jia, Junfeng [1 ]
Zheng, Zhaohui [1 ]
Zhu, Ping [1 ]
机构
[1] Fourth Mil Med Univ, Xying Hosp, Dept Cell Biol Natl Translat Sci, Dept Clin Immunol,Ctr Mol Med, Xian, Peoples R China
[2] Xian Med Univ, Sch Basic Med, Dept Immunol, Xian, Peoples R China
基金
中国国家自然科学基金;
关键词
CD147; T cell; Immune synapse; CD98; TCR signaling; T-CELL-ACTIVATION; IMMUNOGLOBULIN SUPERFAMILY; BASIGIN CD147; ANTIGEN; MEMBER; ROLES; EPITOPES; EMMPRIN; HT7;
D O I
10.1016/j.cellimm.2024.104845
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
CD147 is a T cell activation-associated molecule which is closely involved in the formation of the immune synapse (IS). However, the precise role of CD147 in T cell activation and IS formation remains unclear. In the present study, we demonstrated that CD147 translocated to the IS upon T cell activation and was primarily distributed in the peripheral super molecular cluster (p-SMAC). The knock down of CD147 expression in T cells, but not in B cells, impaired IS formation. CD147 participated in IS formation between T cells and different types of antigen-presenting cells (APCs), including macrophages and dendritic cells. Ligation of CD147 with its monoclonal antibody (mAb) HAb18 effectively inhibited T cell activation and IL-2 secretion. CD98, a critical molecule interacting with CD147, was distributed in IS in a CD147-dependent way. Phosphorylation levels of T cell receptor (TCR) related molecules, like ZAP-70, ERK, and cJun, were down-regulated by CD147 ligation, which is crucial for the interaction of CD147 and TCR signaling transduction. CD147 is indispensable for the formation of immune synapses and plays an important role in the regulation of its function.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] Study of Serum CD147 Level in Patients with Transient Ischemic Attack and CD147 Expression in Atherosclerotic Plaque
    Xu, Bin
    Wu, Chan
    Wu, Wenqing
    Tan, Yanguo
    Sun, Nannan
    Cui, Jian
    Lu, Siyu
    Wang, Jing
    Cen, Shan
    JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2018, 11 (04) : 285 - 291
  • [32] Integrin β1 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147
    Li, Li
    Dong, Xiaoxia
    Peng, Feng
    Shen, Li
    CANCER CELL INTERNATIONAL, 2018, 18
  • [33] CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways
    Wang, Chaoqun
    Fok, Kin Lam
    Cai, Zhiming
    Chen, Hao
    Chan, Hsiao Chang
    ONCOTARGET, 2017, 8 (02) : 3132 - 3143
  • [34] Integrin β1 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147
    Li Li
    Xiaoxia Dong
    Feng Peng
    Li Shen
    Cancer Cell International, 18
  • [35] Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis
    Lv, Jian-Jun
    Wang, Hao
    Cui, Hong-Yong
    Liu, Ze-Kun
    Zhang, Ren-Yu
    Lu, Meng
    Li, Can
    Yong, Yu-Le
    Liu, Man
    Zhang, Hai
    Zhang, Tian-Jiao
    Zhang, Kun
    Li, Gang
    Nan, Gang
    Zhang, Cong
    Guo, Shuang-Ping
    Wang, Ling
    Chen, Zhi-Nan
    Bian, Huijie
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 8
  • [36] The Effects of EMMPRIN/CD147 on Late Function and Histopathological Lesions of the Renal Graft
    Nalewajska, Magdalena
    Opara-Bajerowicz, Martyna
    Safranow, Krzysztof
    Pawlik, Andrzej
    Ciechanowski, Kazimierz
    Kwiatkowski, Sebastian
    Kwiatkowska, Ewa
    BIOLOGY-BASEL, 2022, 11 (02):
  • [37] Targeting the chemotactic function of CD147 reduces collagen-induced arthritis
    Damsker, Jesse M.
    Okwumabua, Ifeanyi
    Pushkarsky, Tatiana
    Arora, Kamalpreet
    Bukrinsky, Michael I.
    Constant, Stephanie L.
    IMMUNOLOGY, 2009, 126 (01) : 55 - 62
  • [38] Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function
    Toole, BP
    CELL SURFACE PROTEASES, 2003, 54 : 371 - 389
  • [39] CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint
    Kosugi, Tomoki
    Maeda, Kayaho
    Sato, Waichi
    Maruyama, Shoichi
    Kadomatsu, Kenji
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30 (07) : 1097 - 1103
  • [40] A novel role of CD147 in immune cell aggregation and inflammation associated tissue injury
    Morgan, A. J.
    Wen, V. W.
    Warner, F. J.
    Potter, A. J.
    Iemma, T.
    Calabro, S.
    Lee, A.
    Fernandez, M. C.
    Yee, C.
    Bowen, D. G.
    Mccaughan, G. W.
    Mclennan, S. V.
    Shackel, N. A.
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 26 : 13 - 13