Mesenchymal stem cell-derived extracellular vesicles for cell-free therapy of ocular diseases

被引：5

作者：

Liu, Xiaoling ^{[1
]}

Hu, Liang ^{[1
]}

Liu, Fei ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Sch Biomed Engn, 270 West Xueyuan Rd, Wenzhou 325000, Zhejiang, Peoples R China

[2] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Zhejiang, Peoples R China

来源：

EXTRACELLULAR VESICLES AND CIRCULATING NUCLEIC ACIDS | 2022年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Mesenchymal stem cells; extracellular vesicles; ophthalmic diseases; therapy; AMELIORATE ALZHEIMERS-DISEASE; IMMUNE-RESPONSES; EXOSOMES; INFLAMMATION; EPITHELIUM; DELIVERY; ROLES; MSC; DEXAMETHASONE; MECHANISMS;

D O I：

10.20517/evcna.2022.08

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) have noticeably attracted clinicians' attention in treating ocular diseases. As the paracrine factor of MSCs and an alternative for cell-free therapies, MSC-EVs can be conveniently dropped over the ocular surface or diffused through the retina upon intravitreal injection, without increasing the risks of cellular rejection and tumor formation. For clinical translation, a standardized and scalable production, as well as reprogramming the MSC-EVs, are highly encouraged. This review aims to assess the potential approaches for EV production and functional modification, in addition to summarizing the worldwide clinical trials initiated for various physiological systems and the specific biochemical effects of MSC-EVs on the therapy of eye diseases. Recent advances in the therapy of ocular diseases based on MSC-EVs are reviewed, and the associated challenges and prospects are discussed as well.

引用

页码：102 / 117

页数：16

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