Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases

被引：2
作者：
Yang, Xiaobo [1 ,2 ,3 ,4 ]
Zhang, Shaodian [1 ,2 ,3 ,4 ]
Lu, Jinwei [1 ,2 ,3 ,4 ]
Chen, Xiaoling [5 ]
Zheng, Tian [1 ,2 ,3 ,4 ]
He, Rongxin [1 ,2 ,3 ,4 ]
Ye, Chenyi [1 ,2 ,3 ,4 ]
Xu, Jianbin [1 ,2 ,3 ,4 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped Surg, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Orthoped Res Inst, Hangzhou, Zhejiang, Peoples R China
[3] Key Lab Motor Syst Dis Res & Precis Therapy Zhejia, Hangzhou, Zhejiang, Peoples R China
[4] Clin Res Ctr Motor Syst Dis Zhejiang Prov, Hangzhou, Peoples R China
[5] Zhejiang Univ, Affiliated Hosp 4, Dept Plast Surg, Sch Med, Yiwu, Zhejiang, Peoples R China
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2024年 / 11卷
基金：
中国国家自然科学基金;
关键词：
MSC-exosomes; skeletal disease; osteoarthritis; osteoporosis; fracture; OSTEOARTHRITIS; OSTEOPOROSIS; INFLAMMATION; APOPTOSIS; PROTECT; RATS;
D O I：
10.3389/fmolb.2024.1268019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such diseases frequently result in complications and are inadequately effective. Research has shifted from conventional therapies based on mesenchymal stem cells (MSCs) to exosomes derived from MSCs. Exosomes are natural nanocarriers of endogenous DNA, RNA, proteins, and lipids and have a low immune clearance rate and good barrier penetration and allow targeted delivery of therapeutics. MSC-derived exosomes (MSC-exosomes) have the characteristics of both MSCs and exosomes, and so they can have both immunosuppressive and tissue-regenerative effects. Despite advances in our knowledge of MSC-exosomes, their regulatory mechanisms and functionalities are unclear. Here we review the therapeutic potential of MSC-exosomes for skeletal diseases.
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页数：15
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