Multiple sclerosis treatment underutilization predicts high risk for obstructive sleep apnea in patients with multiple sclerosis

被引:0
作者
Dempsey, John Patrick [1 ,2 ]
Balshi, Alexandra [1 ]
Bouley, Andrew [3 ]
Egnor, Emily [4 ]
Samaan, Soleil [1 ]
Baber, Ursela [1 ]
Sloane, Jacob A. [1 ]
机构
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA
[2] SUNY, Norton Coll Med, Upstate Med Univ, Syracuse, NY USA
[3] Elliot Lewis Ctr Multiple Sclerosis Care, Wellesley, MA USA
[4] Univ Miami, Leonard M Miller Sch Med, Miami, FL USA
关键词
Obstructive sleep apnea; Disease-modifying therapies; Medication possession ratio; FATIGUE; QUESTIONNAIRE; DISORDERS; SEVERITY; AROUSAL;
D O I
10.1016/j.msard.2024.105889
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Obstructive sleep apnea (OSA) is more common in patients with multiple sclerosis (MS) than in the general population, which suggests MS may predispose patients to OSA. However, the relationships between MS treatment, disease activity, disease severity, fatigue, and OSA are unknown. Objectives: To evaluate the connections between OSA risk, MS fatigue, and MS severity, controlling for wellestablished risk factors for OSA in the general population. Methods: We administered OSA and fatigue-related questionnaires to patients with MS and collected relevant demographic and clinical data. Then, we utilized multivariate logistic regression to examine relationships between OSA risk and MS disease severity. Results: We identified an inverse correlation between medication possession ratio (MPR) and high OSA risk. Statistical models also demonstrated a positive correlation between fatigue and nonwhite race with high OSA risk, controlling for male sex, younger age, and body mass index (BMI). Conclusion: We identified disease-modifying therapy (DMT) underutilization, fatigue, and nonwhite race as predictors of high OSA risk in patients with MS. These findings support aggressive treatment of MS to avoid risk of comorbid OSA and MS-induced fatigue.
引用
收藏
页数:5
相关论文
共 50 条
  • [31] FEATURES OF SLEEP DISTURBANCES IN MULTIPLE SCLEROSIS PATIENTS
    Leonavicius, Rytis
    Adomaitiene, Virginija
    [J]. PSYCHIATRIA DANUBINA, 2014, 26 (03) : 249 - 255
  • [32] Impact of obstructive sleep apnoea on cognitive function in multiple sclerosis: A longitudinal study
    McNicholas, Nuala
    Russell, Audrey
    Nolan, Geraldine
    Tubridy, Niall
    Hutchinson, Michael
    Garvey, John Francis
    McGuigan, Christopher
    [J]. JOURNAL OF SLEEP RESEARCH, 2021, 30 (03)
  • [33] Poor sleep quality in patients with multiple sclerosis: gender differences
    Vitkova, Marianna
    Rosenberger, Jaroslav
    Gdovinova, Zuzana
    Szilasiova, Jarmila
    Mikula, Pavol
    Groothoff, Johan W.
    Reijneveld, Sijmen A.
    van Dijk, Jitse P.
    [J]. BRAIN AND BEHAVIOR, 2016, 6 (11):
  • [34] Sleep quality can influence the outcome of patients with multiple sclerosis
    Buratti, L.
    Iacobucci, D. E.
    Viticchi, G.
    Falsetti, L.
    Lattanzi, S.
    Pulcini, A.
    Silvestrini, M.
    [J]. SLEEP MEDICINE, 2019, 58 : 56 - 60
  • [35] Daclizumab in treatment of multiple sclerosis patients
    Ali, E. N.
    Healy, B. C.
    Stazzone, L. A.
    Brown, B. A.
    Weiner, H. L.
    Khoury, S. J.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2009, 15 (02) : 272 - 274
  • [36] Insufficient sleep: another risk factor for multiple sclerosis
    Aoun, Raissa
    Attarian, Hrayr
    Graham, Edith
    [J]. SLEEP, 2024, 47 (10)
  • [37] Sleep disturbances in multiple sclerosis
    Caminero, Ana
    Bartolome, Manuel
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2011, 309 (1-2) : 86 - 91
  • [38] Sleep Abnormalities in Multiple Sclerosis
    Giorgos K. Sakkas
    Christoforos D. Giannaki
    Christina Karatzaferi
    Mauro Manconi
    [J]. Current Treatment Options in Neurology, 2019, 21
  • [39] Sleep and fatigue in multiple sclerosis
    Stanton, B. R.
    Barnes, F.
    Silber, E.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (04) : 481 - 486
  • [40] Sleep Abnormalities in Multiple Sclerosis
    Sakkas, Giorgos K.
    Giannaki, Christoforos D.
    Karatzaferi, Christina
    Manconi, Mauro
    [J]. CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2019, 21 (01)