A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom

被引：1

作者：

Flinn, Aisling M. ^{[1
,9
]}

Macheka, Sheba ^{[1
]}

Slatter, Mary ^{[1
]}

Ewins, Anna-Maria ^{[2
]}

Gibson, Brenda ^{[2
]}

Lawson, Sarah ^{[3
]}

Tailby, Anna ^{[3
]}

Lucchini, Giovanna ^{[4
]}

New, Helen ^{[5
]}

James, Beki ^{[6
]}

Alfred, Arun ^{[7
]}

Scarisbrick, Julia ^{[8
]}

Gennery, Andrew R. ^{[1
]}

机构：

[1] Great North Childrens Hosp, Dept Paediat Immunol & Haematopoiet Stem Cell Tran, Newcastle Upon Tyne, England

[2] Royal Hosp Children, Haematol Oncol Dept, Glasgow City, Scotland

[3] Birmingham Childrens Hosp, Dept Haematol, Birmingham, England

[4] Great Ormond St Hosp Sick Children, BMT Dept, London, England

[5] London Imperial Coll, NHS Blood & Transplant, London, England

[6] Leeds Childrens Hosp, Reg Ctr Paediat Haematol, Leeds, England

[7] Rotherham Fdn Trust, Dept Photopheresis, Rotherham, England

[8] Univ Hosp Birmingham, Dept Dermatol, Birmingham, England

[9] Great North Childrens Hosp, Newcastle Upon Tyne, England

来源：

EJHAEM | 2020年 / 1卷 / 01期

关键词：

extracorporeal photopheresis; GVHD; immunosuppression; pediatrics; transplantation; PHOTOCHEMOTHERAPY; CHILDREN;

D O I：

10.1002/jha2.58

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Extracorporeal photopheresis (ECP) is a second-line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in low body weight patients. Most patients were on multiple immunosuppressive therapies prior to ECP; 45.9% were able to reduce or stop immunosuppression with treatment. Complete or partial response was reported in almost 60%. This study supports the need to include ECP treatment data to national transplant databases to provide accurate information regarding service provision, patient outcomes, and safety.

引用

页码：293 / 296

页数：4

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