Nickel-Catalyzed, Aminoquinoline-Directed Chemo- and Regioselective Carboamination of Unactivated Olefins with Organoboronic Acids and Anthranils

被引：0

作者：

Xie, Zhongke ^{[1
]}

Cui, Yushan ^{[1
]}

Xing, Jiale ^{[1
]}

Gao, Yang ^{[1
,2
]}

Huo, Yanping ^{[1
]}

Li, Xianwei ^{[1
]}

Chen, Qian ^{[1
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China

[2] Chem & Chem Engn Guangdong Lab, Jieyang Branch, Jieyang 515200, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 19期

基金：

中国国家自然科学基金;

关键词：

ALKENES; HYDROAMINATION;

D O I：

10.1021/acs.joc.4c01536

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed three-component carboamination of unactivated alkenes with organoboronic acids and anthranils has been achieved for the expedient synthesis of delta-aryl and gamma-amino acid derivatives. The 8-aminoquinoline (AQ) directing group is crucial for the success of the reaction, and anthranil serves as an arylnitrene precursor in this conversion. This method features mild reaction conditions, good chemo- and regioselectivity, and a broad substrate scope with good functional group tolerance.

引用

页码：14151 / 14163

页数：13