Success of Combination Therapy with Isavuconazole in a Pediatric Patient with Breakthrough Invasive Aspergillosis

被引：0

作者：

Ozen, Seval ^{[1
]}

Yildiz, Selin ^{[1
]}

Keceli, Avni Merter ^{[2
]}

Kanik-Yuksek, Saliha ^{[1
]}

Guzelkucuk, Zeliha ^{[3
]}

Uzuntas, Sema Turan ^{[4
]}

Gulhan, Belgin ^{[1
]}

Sahin, Elif Ayca ^{[5
]}

Parlakay, Asli Nur Ozkaya ^{[1
]}

Yarali, Nese ^{[3
]}

机构：

[1] Ankara Bilkent City Hosp, Dept Pediat Infect & Dis, Ankara, Turkiye

[2] Ankara Bilkent City Hosp, Dept Radiol, Ankara, Turkiye

[3] Ankara Bilkent City Hosp, Div Pediat Hematol Oncol, Ankara, Turkiye

[4] Ankara Bilkent City Hosp, Dept Med Microbiol, Ankara, Turkiye

[5] Gazi Univ, Dept Med Microbiol, Fac Med, Ankara, Turkiye

来源：

JOURNAL OF PEDIATRIC INFECTIOUS DISEASES | 2024年 / 19卷 / 04期

关键词：

aspergillosis; isavuconazole; salvage treatment; pediatric; VORICONAZOLE;

D O I：

10.1055/s-0044-1788048

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The increasing incidence of invasive fungal infections, coupled with the growing population of immunocompromised patients, has led to an increased need for antifungal agents. The newest azole, isavuconazole, plays an important role in the treatment of invasive aspergillosis in adults due to its broad spectrum, tolerability, and no need for therapeutic drug monitoring. This agent, which has not yet been approved for use in children, has significant problems with drug supply in T & uuml;rkiye. We present the treatment response to isavuconazole combination therapy used in salvage treatment in a patient with breakthrough invasive aspergillosis, who had treatment failure with different antifungal combination treatment options and surgical resection.

引用

页码：242 / 246

页数：5

共 11 条

[1] Population Pharmacokinetics and Pharmacodynamic Target Attainment of Isavuconazole against Aspergillus fumigatus and Aspergillus flavus in Adult Patients with Invasive Fungal Diseases: Should Therapeutic Drug Monitoring for Isavuconazole Be Considered as Mandatory as for the Other Mold-Active Azoles?
Cojutti, Pier Giorgio
Carnelutti, Alessia
Lazzarotto, Davide
Sozio, Emanuela
Candoni, Anna
Fanin, Renato
Tascini, Carlo
Pea, Federico
[J]. PHARMACEUTICS, 2021, 13 (12)
[2] A Case Series and Literature Review of Isavuconazole Use in Pediatric Patients with Hemato-oncologic Diseases and Hematopoietic Stem Cell Transplantation
Decembrino, N.
Perruccio, K.
Zecca, M.
Colombini, A.
Calore, E.
Muggeo, P.
Soncini, E.
Comelli, A.
Molinaro, M.
Goffredo, B. M.
De Gregori, S.
Giardini, I
Scudeller, L.
Cesaro, S.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (03)
[3] Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium
Donnelly, J. Peter
Chen, Sharon C.
Kauffman, Carol A.
Steinbach, William J.
Baddley, John W.
Verweij, Paul E.
Clancy, Cornelius J.
Wingard, John R.
Lockhart, Shawn R.
Groll, Andreas H.
Sorrell, Tania C.
Bassetti, Matteo
Akan, Hamdi
Alexander, Barbara D.
Andes, David
Azoulay, Elie
Bialek, Ralf
Bradsher, Robert W., Jr.
Bretagne, Stephane
Calandra, Thierry
Caliendo, Angela M.
Castagnola, Elio
Cruciani, Mario
Cuenca-Estrella, Manuel
Decker, Catherine F.
Desai, Sujal R.
Fisher, Brian
Harrison, Thomas
Heussel, Claus Peter
Jensen, Henrik E.
Kibbler, Christopher C.
Kontoyiannis, Dimitrios P.
Kullberg, Bart-Jan
Lagrou, Katrien
Lamoth, Frederic
Lehrnbecher, Thomas
Loeffler, Jurgen
Lortholary, Olivier
Maertens, Johan
Marchetti, Oscar
Marr, Kieren A.
Masur, Henry
Meis, Jacques F.
Morrisey, C. Orla
Nucci, Marcio
Ostrosky-Zeichner, Luis
Pagano, Livio
Patterson, Thomas F.
Perfect, John R.
Racil, Zdenek
[J]. CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) : 1367 - 1376
[4] Isavuconazole: Mechanism of Action, Clinical Efficacy, and Resistance
Ellsworth, Misti
Ostrosky-Zeichner, Luis
[J]. JOURNAL OF FUNGI, 2020, 6 (04) : 1 - 10
[5] Challenges in the Treatment of Invasive Aspergillosis in Immunocompromised Children
Hsu, Alice J.
Tamma, Pranita D.
Fisher, Brian T.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2022, 66 (07)
[6] Molecular characterisation of cyp51A and cyp51B genes coding for P450 14α-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus
Krishnan-Natesan, Suganthini
Chandrasekar, Pranatharthi H.
Alangaden, George J.
Manavathu, Elias K.
[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 32 (06) : 519 - 524
[7] Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial
Maertens, Johan A.
Raad, Issam I.
Marr, Kieren A.
Patterson, Thomas F.
Kontoyiannis, Dimitrios P.
Cornely, Oliver A.
Bow, Eric J.
Rahav, Galia
Neofytos, Dionysios
Aoun, Mickael
Baddley, John W.
Giladi, Michael
Heinz, Werner J.
Herbrecht, Raoul
Hope, William
Karthaus, Meinolf
Lee, Dong-Gun
Lortholary, Olivier
Morrison, Vicki A.
Oren, Ilana
Selleslag, Dominik
Shoham, Shmuel
Thompson, George R., III
Lee, Misun
Maher, Rochelle M.
Schmitt-Hoffmann, Anne-Hortense
Zeiher, Bernhardt
Ullmann, Andrew J.
[J]. LANCET, 2016, 387 (10020) : 760 - 769
[8] Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
Patterson, Thomas F.
Thompson, George R., III
Denning, David W.
Fishman, Jay A.
Hadley, Susan
Herbrecht, Raoul
Kontoyiannis, Dimitrios P.
Marr, Kieren A.
Morrison, Vicki A.
Nguyen, M. Hong
Segal, Brahm H.
Steinbach, William J.
Stevens, David A.
Walsh, Thomas J.
Wingard, John R.
Young, Jo-Anne H.
Bennett, John E.
[J]. CLINICAL INFECTIOUS DISEASES, 2016, 63 (04) : E1 - E60
[9] Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteers
Schmitt-Hoffmann, A
Roos, B
Maares, J
Heep, M
Spickerman, J
Weidekamm, E
Brown, T
Roehrle, M
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (01) : 286 - 293
[10] ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children
Warris, A.
Lehrnbecher, T.
Roilides, E.
Castagnola, E.
Bruggemann, R. J. M.
Groll, A. H.
[J]. CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (09) : 1096 - 1113

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