Heterogeneity in Liver Cancer Immune Microenvironment: Emerging Single-Cell and Spatial Perspectives

被引：0

作者：

Li, Caiyi Cherry ^{[1
]}

Liu, Meng ^{[1
]}

Lee, Hsin-Pei ^{[1
]}

Wu, Wenqi ^{[1
]}

Ma, Lichun ^{[1
,2
]}

机构：

[1] NCI, Canc Data Sci Lab, Ctr Canc Res, Bethesda, MD USA

[2] NCI, Liver Canc Program, Ctr Canc Res, Bethesda, MD USA

来源：

SEMINARS IN LIVER DISEASE | 2024年 / 44卷 / 02期

关键词：

liver cancer; tumor immune microenvironment; immunotherapy; single cell and spatial omics; tumor heterogeneity; HEPATOCELLULAR-CARCINOMA; T-CELL; TUMOR MICROENVIRONMENT; DENDRITIC CELLS; B-CELLS; LANDSCAPE; IMMUNOTHERAPY; THERAPY; DIFFERENTIATION; MACROPHAGES;

D O I：

10.1055/s-0044-1787152

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Primary liver cancer is a solid malignancy with a high mortality rate. The success of immunotherapy has shown great promise in improving patient care and highlights a crucial need to understand the complexity of the liver tumor immune microenvironment (TIME). Recent advances in single-cell and spatial omics technologies, coupled with the development of systems biology approaches, are rapidly transforming the landscape of tumor immunology. Here we review the cellular landscape of liver TIME from single-cell and spatial perspectives. We also discuss the cellular interaction networks within the tumor cell community in regulating immune responses. We further highlight the challenges and opportunities with implications for biomarker discovery, patient stratification, and combination immunotherapies.

引用

页码：133 / 146

页数：14

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