Potential role of the intratumoral microbiota in colorectal cancer immunotherapy

被引：6

作者：

Fan, Shiying ^{[1
]}

Zhang, Wenjie ^{[2
]}

Zhou, Lujia ^{[1
]}

Wang, Daorong ^{[3
]}

Tang, Dong ^{[3
]}

机构：

[1] Yangzhou Univ, Clin Med Coll, Yangzhou 225000, Peoples R China

[2] Chongqing Univ, Sch Med, Chongqing 400030, Peoples R China

[3] Yangzhou Univ, Inst Gen Surg, Dept Gen Surg, Northern Jiangsu Peoples Hosp, Yangzhou 225000, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 137卷

关键词：

The intratumoral microbiota; Immunotherapy; Colorectal cancer; Anti -tumor immune response; The gut microbiota; FUSOBACTERIUM-NUCLEATUM; TUMOR-GROWTH; TUMORIGENESIS; IMMUNITY; BINDING; TOXIN; CELLS;

D O I：

10.1016/j.intimp.2024.112537

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Colorectal cancer (CRC) has been one of the most common malignancies worldwide. Despite the advances in current therapies, the mortality rate of CRC remains high. Among them, immunotherapy has achieved satisfactory results in some CRC patients, however, how to expand the use of immunotherapy in CRC patients remains an urgent challenge. Surprisingly, the intratumoral microbiota has been found in multiple tumor tissues, including CRC. It has been demonstrated that the intratumoral microbiota is associated with the progression and treatment of CRC, and is able to enhance or decrease anti -tumor immune responses via different mechanisms as well as influence the immunotherapy efficacy, providing new potential therapeutic targets for CRC immunotherapy. In this review, we focus on the characteristics of the intratumoral microbiota, its roles in the genesis and development of CRC, its modulation of anti -tumor immune responses and immunotherapy, and propose potential applications of the intratumoral microbiota in CRC immunotherapy. Additionally, we propose possible directions for future research on the intratumoral microbiota related to CRC immunotherapy.

引用

页数：11

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