Molecular Imaging of Steroid Receptors in Breast Cancer

被引：1

作者：

Keigley, Quinton J. ^{[1
]}

Fowler, Amy M. ^{[1
,2
,3
]}

O'Brien, Sophia R. ^{[4
]}

Dehdashti, Farrokh ^{[5
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI USA

[2] Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Phys, Madison, WI USA

[4] Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA USA

[5] Washington Univ, Edward Mallinckrodt Inst Radiol, Alvin J Siteman Canc Ctr, Div Nucl Med,Sch Med, 510 S Kingshighway Blvd, St. Louis, MO 63110 USA

来源：

CANCER JOURNAL | 2024年 / 30卷 / 03期

关键词：

Estrogen receptor; progesterone receptor; androgen receptor; positron emission tomography; breast cancer; POSITRON-EMISSION-TOMOGRAPHY; LIGAND-BINDING ASSAY; PHASE-II TRIAL; PROGESTERONE-RECEPTOR; ESTROGEN-RECEPTORS; ENDOCRINE THERAPY; HORMONE RECEPTORS; F-18-FES PET; FES-PET; F-18-FLUOROESTRADIOL PET/CT;

D O I：

10.1097/PPO.0000000000000715

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Steroid receptors regulate gene expression for many important physiologic functions and pathologic processes. Receptors for estrogen, progesterone, and androgen have been extensively studied in breast cancer, and their expression provides prognostic information as well as targets for therapy. Noninvasive imaging utilizing positron emission tomography and radiolabeled ligands targeting these receptors can provide valuable insight into predicting treatment efficacy, staging whole-body disease burden, and identifying heterogeneity in receptor expression across different metastatic sites. This review provides an overview of steroid receptor imaging with a focus on breast cancer and radioligands for estrogen, progesterone, and androgen receptors.

引用

页码：142 / 152

页数：11

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