Evaluating Thromboprophylaxis Strategies for High-Risk Pregnancy: A Current Perspective

被引：4
|
作者：
Stanciakova, Lucia [1 ]
Brisudova, Kristina [2 ]
Skornova, Ingrid [1 ]
Bolek, Tomas [2 ]
Samos, Matej [2 ]
Biringer, Kamil [3 ]
Stasko, Jan [1 ]
Sokol, Juraj [1 ]
机构：
[1] Comenius Univ, Jessenius Fac Med Martin, Natl Ctr Hemostasis & Thrombosis, Dept Hematol & Transfus Med,Martin Univ Hosp, Martin 03601, Slovakia
[2] Comenius Univ, Martin Univ Hosp, Jessenius Fac Med Martin, Dept Internal Med 1, Martin 03601, Slovakia
[3] Comenius Univ, Martin Univ Hosp, Jessenius Fac Med Martin, Dept Gynecol & Obstet, Martin 03601, Slovakia
来源：
PHARMACEUTICALS | 2024年 / 17卷 / 06期
关键词：
risk factors; at-risk pregnant patients; venous thromboembolism; thromboprophylaxis; OVARIAN HYPERSTIMULATION SYNDROME; RECURRENT VENOUS THROMBOEMBOLISM; PHYSIOLOGICAL-CHANGES; THROMBOSIS; PREVENTION; MANAGEMENT; WOMEN; PUERPERIUM; SOCIETY; PATHOPHYSIOLOGY;
D O I：
10.3390/ph17060773
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Venous thromboembolism (VTE) represents one of the leading causes of death during pregnancy. The greatest risk for it is the presence of medical or family history of VTE, stillbirth, cesarean section and selected thrombophilia. Appropriate thromboprophylaxis has the potential to decrease the risk of VTE in at-risk pregnant patients by 60-70%. Based on this, the authors reviewed the PubMed, Web of Science and Scopus databases to identify the possibilities of thromboprophylaxis in pregnant patients with a high risk of VTE. Moreover, they summarized its management in specific situations, such as cesarean delivery or neuraxial blockade. Currently, low-molecular-weight heparins (LMWH) are the preferred drugs for anticoagulant thromboprophylaxis in the course of pregnancy and postpartum due to easy administration and a lower rate of adverse events.
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页数：34
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