Impact of Prior COVID-19 Immunization and/or Prior Infection on Immune Responses and Clinical Outcomes

被引：8

作者：

Livieratos, Achilleas ^{[1
]}

Gogos, Charalambos ^{[1
]}

Akinosoglou, Karolina ^{[1
,2
]}

机构：

[1] Univ Patras, Dept Med, Patras 26504, Greece

[2] Univ Gen Hosp Patras, Dept Internal Med & Infect Dis, Rion 26504, Greece

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 05期

基金：

英国科研创新办公室;

关键词：

SARS-CoV-2; infection; immune responses; humoral immunity; transmission; vaccination; cellular immunity; clinical outcomes; COVID-19; T-CELL RESPONSES; MESSENGER-RNA VACCINE; PERIPHERAL-BLOOD; SARS-COV-2; IMMUNOGENICITY; DISEASE; ANTIBODY; HEALTH; ADULT;

D O I：

10.3390/v16050685

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cellular and humoral immunity exhibit dynamic adaptation to the mutating SARS-CoV-2 virus. It is noteworthy that immune responses differ significantly, influenced by whether a patient has received vaccination or whether there is co-occurrence of naturally acquired and vaccine-induced immunity, known as hybrid immunity. The different immune reactions, conditional on vaccination status and the viral variant involved, bear implications for inflammatory responses, patient outcomes, pathogen transmission rates, and lingering post-COVID conditions. Considering these developments, we have performed a review of recently published literature, aiming to disentangle the intricate relationships among immunological profiles, transmission, the long-term health effects post-COVID infection poses, and the resultant clinical manifestations. This investigation is directed toward understanding the variability in the longevity and potency of cellular and humoral immune responses elicited by immunization and hybrid infection.

引用

页数：15

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